Oliveto A H, Dykstra L A
Pharmacol Biochem Behav. 1987 Jan;26(1):191-3. doi: 10.1016/0091-3057(87)90554-5.
In order to explore the conditions under which sensitivity to naloxone develops, naloxone's effects were examined in squirrel monkeys responding under a discrete trial schedule of shock titration. Naloxone's effects were examined prior to and following a chronic naloxone regimen in which 10 mg/kg of naloxone was administered daily for at least 21 days. The level at which monkeys maintained the shock and rates of responding were recorded. Prior to chronic administration, selective doses (1.0, 3.0 mg/kg) of naloxone decreased shock levels slightly. These decreases were accompanied by increases in response rates. Subsequent to chronic administration, shock levels were unaltered; however, rates of responding showed greater increases. These results suggest that, following chronic naloxone exposure, animals responding under a schedule of shock titration became more sensitive to the rate-increasing effects of naloxone, but not to naloxone's effects on shock intensity.
为了探究对纳洛酮产生敏感性的条件，在松鼠猴按照电击滴定的离散试验程序做出反应时，对纳洛酮的作用进行了检测。在一个慢性纳洛酮给药方案之前和之后检测了纳洛酮的作用，该方案中每天给予10mg/kg的纳洛酮，持续至少21天。记录猴子维持电击的水平和反应速率。在慢性给药之前，选择性剂量（1.0、3.0mg/kg）的纳洛酮使电击水平略有降低。这些降低伴随着反应速率的增加。慢性给药之后，电击水平未改变；然而，反应速率有更大的增加。这些结果表明，在慢性接触纳洛酮之后，按照电击滴定程序做出反应的动物对纳洛酮的速率增加作用变得更加敏感，但对纳洛酮对电击强度的作用不敏感。
