Genovese R F, Dykstra L A
Life Sci. 1986 Nov 10;39(19):1713-9. doi: 10.1016/0024-3205(86)90089-5.
The analgesic efficacy of the kappa-opioid benzodiazepine, tifluadom, was examined in squirrel monkeys using electric shock titration and tail-immersion procedures. Tifluadom produced dose-dependent increases in the shock intensity that maintained responding under the shock titration schedule without substantially decreasing response rates. Tifluadom also increased the latency of tail-withdrawal from 55 degrees C water. Naloxone attenuated tifluadom's effects under both procedures. These results extend previous reports of tifluadom's analgesic characteristics and suggest that the tail-immersion procedure is a useful analgesic assay in squirrel monkeys.
使用电击滴定法和尾部浸入法，在松鼠猴身上检测了κ-阿片类苯二氮䓬类药物替氟朵的镇痛效果。在电击滴定程序下，替氟朵能使维持反应的电击强度呈剂量依赖性增加，且不会大幅降低反应率。替氟朵还延长了从55摄氏度水中抽回尾巴的潜伏期。在这两种程序下，纳洛酮均减弱了替氟朵的作用。这些结果扩展了先前关于替氟朵镇痛特性的报道，并表明尾部浸入法是一种用于检测松鼠猴镇痛效果的有效方法。
