Williams S F, Herberg L J
Pharmacol Biochem Behav. 1987 Jan;26(1):49-55. doi: 10.1016/0091-3057(87)90532-6.
Four GABA-terminal sites downstream from the rat corpus striatum were injected bilaterally with either a GABA agonist (muscimol 15-250 ng) or antagonist (picrotoxin 15-300 ng), and the effects on spontaneous locomotor activity or variable-interval hypothalamic self-stimulation were recorded. Significant changes in locomotor activity were produced at all four sites, as in previous studies. Two of the sites tested, the anterior globus pallidus and the thalamic ventromedial nucleus, also receive gabergic projections from the nucleus accumbens or from structures other than the basal ganglia; at these two sites, injection of either muscimol (depressant), or picrotoxin (facilitatory), had the same effect on self-stimulation as on locomotor activity. The two other sites tested, the entopeduncular nucleus and subthalamic nucleus, do not receive projections from the accumbens; in these two structures, muscimol enhanced locomotor activity but abolished self-stimulation; picrotoxin was without significant effect, or was disruptive. These results confirm previous reports that gabergic systems downstream from the striatum can mediate a simple, innate motor sequence (locomotion), but they fail to demonstrate a specific involvement of these pathways in learned behaviour (self-stimulation).
在大鼠纹状体下游的四个γ-氨基丁酸（GABA）终末位点双侧注射GABA激动剂（蝇蕈醇15 - 250纳克）或拮抗剂（印防己毒素15 - 300纳克），并记录其对自发运动活动或可变间隔下丘脑自我刺激的影响。与之前的研究一样，在所有四个位点均产生了运动活动的显著变化。所测试的两个位点，即苍白球前部和丘脑腹内侧核，也接受来自伏隔核或基底神经节以外结构的GABA能投射；在这两个位点，注射蝇蕈醇（抑制性）或印防己毒素（促进性）对自我刺激的影响与对运动活动的影响相同。另外两个测试位点，即内苍白球核和丘脑底核，不接受来自伏隔核的投射；在这两个结构中，蝇蕈醇增强了运动活动但消除了自我刺激；印防己毒素没有显著影响，或具有干扰作用。这些结果证实了之前的报道，即纹状体下游的GABA能系统可以介导一个简单的、天生的运动序列（运动），但未能证明这些通路在学习行为（自我刺激）中有特定参与。
