Talalaenko A N, Krivobok G K, Bulgakova N P, Pankrat'ev D V
Department of Pharmacology, Laboratory for Behavioral Physiology and Pharmacology, Central Research Laboratory, M. Gor'kii Donetsk State Medical University, Ukraine.
Neurosci Behav Physiol. 2008 Feb;38(2):115-8. doi: 10.1007/s11055-008-0016-0.
Microinjections of serotonin and glutamic acid into the globus pallidus in conditions of free selection between a light and a dark chamber showed these substances to have antiaversive activity in rats in the "threatening situation" test but not in the "illuminated area" test. Local administration of dopamine and GABA into this basal ganglia formation had no effect on the mechanisms of voluntary movement but countered anxiety states in both behavioral models. These results provide evidence that the neurotransmitter systems of the dorsal pallidum have different degrees of involvement in the operative control of behavior when the modality of the aversive stimulus changes.
在明暗室自由选择条件下，向苍白球微量注射血清素和谷氨酸的实验表明，在“威胁情境”测试中，这些物质对大鼠具有抗厌恶活性，但在“光照区域”测试中则不然。向该基底神经节结构局部注射多巴胺和GABA对自主运动机制没有影响，但在两种行为模型中都能对抗焦虑状态。这些结果证明，当厌恶刺激的形式发生变化时，背侧苍白球的神经递质系统在行为的操作控制中参与程度不同。
