Todisco Simona, Santarsiero Anna, Convertini Paolo, De Stefano Giulio, Gilio Michele, Iacobazzi Vito, Infantino Vittoria
Department of Science, University of Basilicata, Viale dell'Ateneo Lucano 10, 85100 Potenza, Italy.
Department of Infectious Diseases, San Carlo Hospital, Via Potito Petrone, 85100 Potenza, Italy.
Biology (Basel). 2022 May 23;11(5):792. doi: 10.3390/biology11050792.
The strong relationship between metabolic alterations and non-alcoholic steatohepatitis (NASH) suggests a pathogenic interplay. However, many aspects have not yet been fully clarified. Nowadays, NASH is becoming the main cause of liver-associated morbidity and mortality. Therefore, an effort to understand the mechanisms underlying the pathogenesis of NASH is critical. Among the nuclear receptor transcription factors, peroxisome-proliferator-activated receptor alpha (PPARα) is highly expressed in the liver, where it works as a pivotal transcriptional regulator of the intermediary metabolism. In this context, PPARα's function in regulating the lipid metabolism is essential for proper liver functioning. Here, we review metabolic liver genes under the control of PPARα and discuss how this aspect can impact the inflammatory condition and pathogenesis of NASH.
代谢改变与非酒精性脂肪性肝炎（NASH）之间的紧密关系提示了一种致病的相互作用。然而，许多方面尚未完全阐明。如今，NASH正成为肝脏相关发病和死亡的主要原因。因此，努力理解NASH发病机制背后的机制至关重要。在核受体转录因子中，过氧化物酶体增殖物激活受体α（PPARα）在肝脏中高度表达，在那里它作为中间代谢的关键转录调节因子发挥作用。在这种情况下，PPARα在调节脂质代谢中的功能对于肝脏的正常运作至关重要。在此，我们综述受PPARα调控的代谢性肝脏基因，并讨论这一方面如何影响NASH的炎症状态和发病机制。
