Department of Molecular Biology and Research Direction, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico.
Department of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico.
Biomolecules. 2022 Apr 19;12(5):601. doi: 10.3390/biom12050601.
FOXA3 is a transcription factor involved in the macrophage cholesterol efflux and macrophage reverse cholesterol transport reducing the atherosclerotic lesions. Thus, the present study aimed to establish if the FOXA3 polymorphisms are associated with subclinical atherosclerosis (SA) and cardiometabolic parameters. Two FOXA3 polymorphisms (rs10410870 and rs10412574) were determined in 386 individuals with SA and 1070 controls. No association with SA was observed. The rs10410870 polymorphism was associated with a low risk of having total cholesterol >200 mg/dL, non-HDL-cholesterol > 160 mg/dL, and a high risk of having LDL pattern B and insulin resistance adipose tissue in individuals with SA, and with a high risk of having interleukin 10
FOXA3 是一种转录因子，参与巨噬细胞胆固醇流出和巨噬细胞逆向胆固醇转运，从而减少动脉粥样硬化病变。因此，本研究旨在确定 FOXA3 多态性是否与亚临床动脉粥样硬化 (SA) 和心脏代谢参数相关。在 386 名 SA 患者和 1070 名对照者中确定了两个 FOXA3 多态性(rs10410870 和 rs10412574)。未观察到与 SA 的关联。rs10410870 多态性与 SA 患者总胆固醇>200mg/dL、非高密度脂蛋白胆固醇>160mg/dL、LDL 模式 B 和脂肪组织胰岛素抵抗的低风险相关，与 IL-10<p25 和镁缺乏的高风险相关控制。rs10412574 多态性与 SA 患者脂肪组织胰岛素抵抗的低风险和天冬氨酸转氨酶>p75 的高风险相关，与 LDL 模式 B 的低风险和镁缺乏的高风险相关控制。在 846 名个体中的独立分析表明，rs10410870 多态性与主动脉瓣钙化的高风险相关。总之，FOXA3 多态性与 SA 无关；然而，它们与 SA 患者和无 SA 患者的心脏代谢参数相关。
