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多巴胺调节腹侧纹状体中食物气味的处理过程。

Dopamine Modulates the Processing of Food Odour in the Ventral Striatum.

作者信息

Rampin Olivier, Saint Albin Deliot Audrey, Ouali Christian, Burguet Jasmine, Gry Elisa, Champeil Potokar Gaelle, Jérôme Nathalie, Davidenko Olga, Darcel Nicolas, Bombail Vincent, Andrey Philippe, Denis Isabelle

机构信息

Université Paris-Saclay, AgroParisTech, INRAE, UMR PNCA, 75005 Paris, France.

Institut Jean-Pierre Bourgin (IJPB), Université Paris-Saclay, INRAE, AgroParisTech, 78000 Versailles, France.

出版信息

Biomedicines. 2022 May 12;10(5):1126. doi: 10.3390/biomedicines10051126.

DOI:10.3390/biomedicines10051126
PMID:35625863
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9138215/
Abstract

Food odour is a potent stimulus of food intake. Odour coding in the brain occurs in synergy or competition with other sensory information and internal signals. For eliciting feeding behaviour, food odour coding has to gain signification through enrichment with additional labelling in the brain. Since the ventral striatum, at the crossroads of olfactory and reward pathways, receives a rich dopaminergic innervation, we hypothesized that dopamine plays a role in food odour information processing in the ventral striatum. Using single neurones recordings in anesthetised rats, we show that some ventral striatum neurones respond to food odour. This neuronal network displays a variety of responses (excitation, inhibition, rhythmic activity in phase with respiration). The localization of recorded neurones in a 3-dimensional brain model suggests the spatial segregation of this food-odour responsive population. Using local field potentials recordings, we found that the neural population response to food odour was characterized by an increase of power in the beta-band frequency. This response was modulated by dopamine, as evidenced by its depression following administration of the dopaminergic D1 and D2 antagonists SCH23390 and raclopride. Our results suggest that dopamine improves food odour processing in the ventral striatum.

摘要

食物气味是食物摄入的一种有力刺激因素。大脑中的气味编码与其他感官信息和内部信号协同或竞争发生。为了引发进食行为，食物气味编码必须通过在大脑中添加额外的标记来获得意义。由于腹侧纹状体处于嗅觉和奖赏通路的交叉点，接受丰富的多巴胺能神经支配，我们推测多巴胺在腹侧纹状体的食物气味信息处理中起作用。通过在麻醉大鼠中进行单神经元记录，我们发现一些腹侧纹状体神经元对食物气味有反应。这个神经网络表现出多种反应（兴奋、抑制、与呼吸同步的节律性活动）。在三维脑模型中记录神经元的定位表明，这个对食物气味有反应的群体在空间上是分离的。通过局部场电位记录，我们发现神经群体对食物气味的反应以β波段频率的功率增加为特征。这种反应受到多巴胺的调节，多巴胺能D1和D2拮抗剂SCH23390和雷氯必利给药后反应受到抑制证明了这一点。我们的结果表明，多巴胺改善了腹侧纹状体中的食物气味处理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd3/9138215/fc5b6709bdad/biomedicines-10-01126-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd3/9138215/0b98e21a745f/biomedicines-10-01126-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd3/9138215/47abb2eaf458/biomedicines-10-01126-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd3/9138215/3ae76ad7b169/biomedicines-10-01126-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd3/9138215/bb309a6c3b0c/biomedicines-10-01126-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd3/9138215/9db1ab875d63/biomedicines-10-01126-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd3/9138215/ad2fc3fa2de5/biomedicines-10-01126-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd3/9138215/b0ca2d528c1c/biomedicines-10-01126-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd3/9138215/76ca3274d8f2/biomedicines-10-01126-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd3/9138215/fc5b6709bdad/biomedicines-10-01126-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd3/9138215/0b98e21a745f/biomedicines-10-01126-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd3/9138215/47abb2eaf458/biomedicines-10-01126-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd3/9138215/3ae76ad7b169/biomedicines-10-01126-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd3/9138215/bb309a6c3b0c/biomedicines-10-01126-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd3/9138215/9db1ab875d63/biomedicines-10-01126-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd3/9138215/ad2fc3fa2de5/biomedicines-10-01126-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd3/9138215/b0ca2d528c1c/biomedicines-10-01126-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd3/9138215/76ca3274d8f2/biomedicines-10-01126-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dd3/9138215/fc5b6709bdad/biomedicines-10-01126-g009.jpg

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