Wu Jiahang, Chen Taijun, Wang Yingying, Bai Jiafan, Lao Chenwen, Luo Minyue, Chen Mingxia, Peng Wenzhen, Zhi Wei, Weng Jie, Wang Jianxin
Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
Chengdu Yikeda Biotechnology Co., Ltd., Chengdu 610095, China.
Biomedicines. 2022 May 18;10(5):1165. doi: 10.3390/biomedicines10051165.
The lack of vascular tissue and the low metabolism and biological activity of mature chondrocytes lead to the low regeneration ability of articular cartilage. People try to solve this problem through various methods, but the effect is not very ideal. Inspired by the piezoelectric effect of collagen in cartilage tissue, this work focused on the design of a biomimetic hydrogel by introducing piezoelectric materials and silver nanowires into hydrogel to endow them with piezoelectric and antibacterial properties to promote tissue regeneration. Additionally, the mechanical and swelling properties of the material were adjusted to match natural articular cartilage. Based on bionic principles, a double-layer piezoelectric hydrogel was prepared and applied for the repair of osteochondral defects. An enhanced repair effect of osteochondral defects has been seen, which has demonstrated potential values for future application in bionics principle- and piezoelectric effect-based osteochondral tissue engineering. Furthermore, piezoelectric effect-induced degradation was observed. These results fully indicated the positive effect of the piezoelectric effect on promoting the regeneration of osteochondral tissue and in vivo degradation of materials.
缺乏血管组织以及成熟软骨细胞的低代谢和生物活性导致关节软骨的再生能力较低。人们试图通过各种方法解决这个问题，但效果不太理想。受软骨组织中胶原蛋白压电效应的启发，这项工作专注于通过将压电材料和银纳米线引入水凝胶来设计一种仿生水凝胶，赋予其压电和抗菌性能以促进组织再生。此外，还对材料的机械性能和溶胀性能进行了调整，使其与天然关节软骨相匹配。基于仿生原理，制备了双层压电水凝胶并将其应用于骨软骨缺损的修复。已观察到骨软骨缺损的修复效果增强，这表明其在基于仿生原理和压电效应的骨软骨组织工程中的未来应用具有潜在价值。此外，还观察到压电效应诱导的降解。这些结果充分表明了压电效应在促进骨软骨组织再生和材料体内降解方面的积极作用。
