Carrieri Livianna, Osella Alberto Ruben, Ciccacci Fausto, Giannelli Gianluigi, Scavo Maria Principia
Personalized Medicine Laboratory, National Institute of Gastroenterology IRCCS "S. de Bellis" Research Hospital, Via Turi 27, 70013 Castellana Grotte, Italy.
Laboratory of Epidemiology and Biostatistics, National Institute of Gastroenterology IRCCS "S. de Bellis" Research Hospital, Via Turi 27, 70013 Castellana Grotte, Italy.
Biomedicines. 2022 May 20;10(5):1184. doi: 10.3390/biomedicines10051184.
Non-alcoholic fatty liver disease (NAFLD) is a multifactorial condition that affects 25% of the world's population. There is a clear difference in both geographical distribution and sex in childbearing age. These differences are reduced when women become older and senescence begins. The factors that affect the likelihood of developing NAFLD in a premenopausal woman are an imbalance of sex hormones (especially in estradiol and androgen), microbiome dysregulation, insulin resistance, early menarche, the length of time that the woman breastfeeds for and polycystic ovarian syndrome (PCOS). The aim of this review is to identify various physical ailments that may not appear to be serious to young women but that then affect the onset of NAFLD in perimenopause and can degenerate into NASH. These conditions should also be considered in future clinical management, as well as in research opportunities, in order to customize the monitoring and treatment of NAFLD, considering gender medicine for those women who had early metabolic symptoms that were not considered to be significant at the time.
非酒精性脂肪性肝病（NAFLD）是一种影响全球25%人口的多因素疾病。在地理分布和育龄期性别方面存在明显差异。当女性年龄增长并开始衰老时，这些差异会减小。影响绝经前女性患NAFLD可能性的因素包括性激素失衡（尤其是雌二醇和雄激素）、微生物群失调、胰岛素抵抗、初潮过早、母乳喂养时间长短以及多囊卵巢综合征（PCOS）。本综述的目的是识别各种对年轻女性看似不严重，但随后会影响围绝经期NAFLD发病并可能恶化为非酒精性脂肪性肝炎（NASH）的身体疾病。在未来的临床管理以及研究机会中，也应考虑这些情况，以便针对那些当时被认为不严重的早期代谢症状的女性，根据性别医学定制NAFLD的监测和治疗。
