Medica Sur Clinic and Foundation, Mexico City, Mexico.
Ann Hepatol. 2010 Oct-Dec;9(4):402-9.
BACKGROUND & AIM: Non alcoholic fatty liver disease (NAFLD) is the most common liver disease in Western countries. Population studies have demonstrated that men and posmenopausal women have higher prevalence of NAFLD. The aim was to investigate the prevalence of NAFLD in premenopausal, posmenopausal and polycystic ovary syndrome (PCOS) women.
A cross sectional study carried out at University Hospital in Mexico City from January 2009 to November 2009. One hundred ninety seven women who agreed to participate were divided into groups, comprising 93 with NAFLD and without NAFLD. Anthropometric, metabolic and biochemical variables were measured. Serum estradiol and cortisol concentrations were determined and compared between the groups.
Of the 197 patients, 93(47.2%) had NAFLD and 104 (52.8%) did not have NAFLD. The prevalence of NAFLD in premenopausal, postmenopausal and PCOS patients was 32.2, 57.9, and 62%, respectively. Age, BMI, hip to waist ratio, fasting glucose, HOMA -IR, and insulin were significantly higher in NAFLD patients. Women without NAFLD had significantly higher levels of serum estradiol (100 ± 95.4) compared with NAFLD patients (55.5 ± 66.6) p = 0.001. By group with and without NAFLD: premenopausal (55.44±93.3 vs. 128.56 ± 109.22), posmenopausal (44.98 ± 51.41 vs. 42.72 ± 51.48) and PCOS women (64.9 ± 53.3 vs. 101.36 ± 80.89) had significantly different hormone profile.
These results suggest that NAFLD is more prevalent in postmenopausal and women with PCOS than those premenopausal ones. The estrogens may have a protective effect of against NAFLD in women.
非酒精性脂肪性肝病（NAFLD）是西方国家最常见的肝脏疾病。人群研究表明，男性和绝经后女性的 NAFLD 患病率更高。本研究旨在调查绝经前、绝经后和多囊卵巢综合征（PCOS）妇女中 NAFLD 的患病率。
这是一项 2009 年 1 月至 11 月在墨西哥城大学医院进行的横断面研究。共纳入 197 名同意参与的女性，分为有和无 NAFLD 两组。测量了人体测量学、代谢和生化变量。检测并比较了两组患者的血清雌二醇和皮质醇浓度。
197 名患者中，93 名（47.2%）患有 NAFLD，104 名（52.8%）无 NAFLD。绝经前、绝经后和 PCOS 患者的 NAFLD 患病率分别为 32.2%、57.9%和 62%。NAFLD 患者的年龄、BMI、腰臀比、空腹血糖、HOMA-IR 和胰岛素均显著升高。无 NAFLD 的女性血清雌二醇水平显著高于 NAFLD 患者[（100±95.4）pg/ml 比（55.5±66.6）pg/ml，p=0.001]。按有无 NAFLD 分组：绝经前（55.44±93.3 比 128.56±109.22）、绝经后（44.98±51.41 比 42.72±51.48）和 PCOS 患者（64.9±53.3 比 101.36±80.89）的激素谱有显著差异。
这些结果表明，绝经后和 PCOS 女性的 NAFLD 患病率高于绝经前女性。雌激素可能对女性的 NAFLD 具有保护作用。
