Kim Yongseon, Kim Yong-Seok, Bae Ja Seong, Kim Jeong Soo, Kim Kwangsoon
Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Cancers (Basel). 2022 May 11;14(10):2370. doi: 10.3390/cancers14102370.
The presence of extrathyroidal extension (ETE) is associated with locoregional recurrence and distant metastases in papillary thyroid carcinoma (PTC). This study was designed to compare the recurrence risk between minimal ETE (mETE) and gross ETE (gETE) in patients with PTC using propensity score matching. In this study, 4452 patients with PTC who underwent thyroid surgery in a single center were retrospectively analyzed, and clinicopathological characteristics were compared according to the ETE status. Disease-free survival (DFS) and recurrence risk were compared between mETE and gETE after propensity score matching. The mean follow-up duration was 122.7 ± 22.5 months. In multivariate analysis, both mETE and gETE were not associated with recurrence risk before propensity score matching ( = 0.154 and = 0.072, respectively). After propensity score matching, no significant difference in recurrence rates was observed between the two groups ( = 0.668). DFS of the gETE group did not significantly differ from that of the mETE group (log-rank = 0.531). This study revealed that both mETE and gETE are not independent risk factors for the risk of recurrence in PTC. Our findings suggest that gETE invading strap muscles only might not be associated with worse oncological outcomes in PTC.
甲状腺外侵犯（ETE）的存在与甲状腺乳头状癌（PTC）的局部区域复发和远处转移相关。本研究旨在使用倾向评分匹配法比较PTC患者中微小ETE（mETE）和大体ETE（gETE）之间的复发风险。在本研究中，对在单一中心接受甲状腺手术的4452例PTC患者进行了回顾性分析，并根据ETE状态比较了临床病理特征。在倾向评分匹配后，比较了mETE和gETE之间的无病生存期（DFS）和复发风险。平均随访时间为122.7±22.5个月。在多变量分析中，在倾向评分匹配前，mETE和gETE均与复发风险无关（分别为=0.154和=0.072）。倾向评分匹配后，两组之间未观察到复发率的显著差异（=0.668）。gETE组的DFS与mETE组无显著差异（对数秩检验=0.531）。本研究表明，mETE和gETE均不是PTC复发风险的独立危险因素。我们的研究结果表明，仅侵犯带状肌的gETE可能与PTC更差的肿瘤学结局无关。
