Almushayt Shatha J, Pham Alisa, Phillips Bethan E, Williams John P, Taal Maarten W, Selby Nicholas M
Centre for Kidney Research and Innovation (CKRI), University of Nottingham, Nottingham DE22 3DT, UK.
Department of Renal Medicine, Derby Hospitals NHS Foundation Trust, Derby DE22 3DT, UK.
Diagnostics (Basel). 2022 May 23;12(5):1293. doi: 10.3390/diagnostics12051293.
Alterations in renal perfusion play a major role in the pathogenesis of renal diseases. Renal contrast-enhanced ultrasound (CEUS) is increasingly applied to quantify renal cortical perfusion and to assess its change over time, but comprehensive assessment of the technique's repeatability is lacking. Ten adults attended two renal CEUS scans within 14 days. In each session, five destruction/reperfusion sequences were captured. One-phase association was performed to derive the following parameters: acoustic index (AI), mean transit time (mTT), perfusion index (PI), and wash-in rate (WiR). Intra-individual and inter-operator (image analysis) repeatability for the perfusion variables were assessed using intra-class correlation (ICC), with the agreement assessed using a Bland-Altman analysis. The 10 adults had a median (IQR) age of 39 years (30-46). Good intra-individual repeatability was found for mTT (ICC: 0.71) and PI (ICC: 0.65). Lower repeatability was found for AI (ICC: 0.50) and WiR (ICC: 0.56). The correlation between the two operators was excellent for all variables: the ICCs were 0.99 for PI, 0.98 for AI, 0.87 for mTT, and 0.83 for WiR. The Bland-Altman analysis showed that the mean biases (± SD) between the two operators were 0.03 ± 0.16 for mTT, 0.005 ± 0.09 for PI, 0.04 ± 0.19 for AI, and -0.02 ± 0.11 for WiR.
肾灌注改变在肾脏疾病的发病机制中起主要作用。肾对比增强超声（CEUS）越来越多地用于量化肾皮质灌注并评估其随时间的变化，但缺乏对该技术可重复性的全面评估。10名成年人在14天内接受了两次肾CEUS扫描。在每次检查中，采集了五个破坏/再灌注序列。进行单相关联以得出以下参数：声学指数（AI）、平均通过时间（mTT）、灌注指数（PI）和洗入率（WiR）。使用组内相关系数（ICC）评估灌注变量的个体内和操作者间（图像分析）可重复性，并使用Bland-Altman分析评估一致性。这10名成年人的年龄中位数（四分位间距）为39岁（30 - 46岁）。发现mTT（ICC：0.71）和PI（ICC：0.65）具有良好的个体内可重复性。AI（ICC：0.50）和WiR（ICC：0.56）的可重复性较低。两名操作者之间所有变量的相关性都非常好：PI的ICC为0.99，AI为0.98，mTT为0.87，WiR为0.83。Bland-Altman分析表明，两名操作者之间的平均偏差（±标准差）mTT为0.03 ± 0.16，PI为0.005 ± 0.09，AI为0.04 ± 0.19，WiR为 -0.02 ± 0.11。
