Shulan (Hangzhou) Hospital Affiliated to Zhejiang Shuren University Shulan International Medical College, Hangzhou 310004, China.
School of Medicine, Zhejiang University, Hangzhou 310003, China.
Genes (Basel). 2022 May 13;13(5):876. doi: 10.3390/genes13050876.
Hepatocellular carcinoma (HCC) is the predominant form of liver cancer and is accompanied by a complex regulatory network. Increasing evidence suggests that an abnormal gene expression of is associated with HCC progression. However, the molecular mechanism by which non-coding RNAs (ncRNAs) regulate remains elusive.
The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) data were used to perform differential expression analysis and prognostic analysis. We used the Encyclopedia of RNA Interactomes (ENCORI) database to predict candidate miRNAs and lncRNAs that may bind to . Subsequently, the comprehensive analysis (including expression analysis, correlation analysis, and survival analysis) identified ncRNAs that contribute to overexpression.
was found to be upregulated in the majority of tumor types and associated with a poor prognosis. Hsa-miR-101-3p was identified as a target miRNA of . Additionally, SNHG6 and MALAT1 were identified as upstream lncRNAs of hsa-miR-101-3p. Meanwhile, correlation analysis revealed that expression was significantly associated with the infiltration of several immune cell types in HCC.
SNHG6 or MALAT1/hsa-miR-101-3p/ axis were identified as potential regulatory pathways in the progression of HCC.
肝细胞癌（HCC）是肝癌的主要形式，伴随着复杂的调控网络。越来越多的证据表明，异常的 基因表达与 HCC 的进展有关。然而，非编码 RNA（ncRNA）调节 的分子机制尚不清楚。
使用癌症基因组图谱（TCGA）和基因型组织表达（GTEx）数据进行差异表达分析和预后分析。我们使用 RNA 相互作用百科全书（ENCORI）数据库来预测可能与 结合的候选 miRNA 和 lncRNA。随后，通过全面分析（包括表达分析、相关性分析和生存分析）确定了导致 过表达的 ncRNA。
在大多数肿瘤类型中均上调，与预后不良相关。hsa-miR-101-3p 被鉴定为 的靶 miRNA。此外，SNHG6 和 MALAT1 被鉴定为 hsa-miR-101-3p 的上游 lncRNA。同时，相关性分析表明， 在 HCC 中与几种免疫细胞类型的浸润显著相关。
SNHG6 或 MALAT1/hsa-miR-101-3p/ 轴被鉴定为 HCC 进展中的潜在调节途径。
