Hiroshige T, Shiraishi I, Hirai T, Honma K, Honma S, Katsuno Y
Psychoneuroendocrinology. 1986;11(4):407-13. doi: 10.1016/0306-4530(86)90002-8.
To characterize the prandial plasma corticosterone peak, three experiments were done on adult male Wistar rats: (1) the prandial hormone peak was followed at three different times of day, 0800 h, 1900 h, and 0100 h, in starved rats; (2) a 20% glucose solution was infused into the jugular vein or was given as a drinking solution after a 24-h starvation; (3) in order to determine the role of vagal proprioceptive inputs, the hormone peak was examined at two times of day, 0800 h and 0100 h, in starved vagotomized rats. The prandial hormone peak was more conspicuous at midnight than in the daytime. Exposure to food pellets without feeding failed to induce a hormone rise. The peak appeared after oral ingestion, but not after intravenous infusion, of glucose solution. Ingestion of water alone was without effect. The peak was not affected by bilateral vagotomy. Thus, as far as glucose as a metabolite is concerned, the possibility that glucose per se works directly on the brain or indirectly through glucoreceptors in the gut was excluded. Possible modes of action of glucose ingestion are discussed.
为了描述餐后血浆皮质酮峰值的特征，对成年雄性Wistar大鼠进行了三项实验：（1）在饥饿大鼠中，于一天中的三个不同时间点（08:00、19:00和01:00）追踪餐后激素峰值；（2）在禁食24小时后，将20%的葡萄糖溶液注入颈静脉或作为饮用溶液给予；（3）为了确定迷走神经本体感觉输入的作用，在饥饿的迷走神经切断大鼠中，于一天中的两个时间点（08:00和01:00）检查激素峰值。午夜时的餐后激素峰值比白天更明显。接触未喂食的食丸未能诱导激素升高。葡萄糖溶液经口服摄入后出现峰值，但静脉输注后未出现。仅摄入水没有效果。峰值不受双侧迷走神经切断术的影响。因此，就葡萄糖作为一种代谢物而言，排除了葡萄糖本身直接作用于大脑或通过肠道中的葡萄糖受体间接作用的可能性。讨论了葡萄糖摄入的可能作用方式。
