Shiraishi I, Honma K, Honma S, Hiroshige T
Am J Physiol. 1984 Jul;247(1 Pt 2):R40-5. doi: 10.1152/ajpregu.1984.247.1.R40.
An ethosecretogram, which illustrates the phase relation between animal behavior and plasma hormone levels, was constructed in conscious rats. A catheter was placed into the right atrium in male rats 2 days before blood sampling. Plasma corticosterone levels were monitored individually through the catheter every 5 min over a period of several hours under freely moving conditions on an Animex, which records spontaneous locomotor activity. The results showed that the bursts of locomotor activity were temporally correlated with those of plasma corticosterone level, the peak of the former preceding the hormone peak by 15 min. Regarding the type of locomotor activity, feeding and grooming were significantly correlated with the subsequent hormone elevation, whereas drinking was not. In a separate series of experiments, effects of feeding and drinking on plasma corticosterone levels were examined in conscious rats that had been fasted or water deprived for 24 or 48 h. In both cases, feeding induced a more pronounced elevation than drinking, although locomotor activity counts per se increased more sharply in the latter. It is concluded that in the ethosecretogram specific types of locomotor activity such as feeding and grooming induce a phase-locked elevation of plasma corticosterone under freely moving conditions.
在清醒大鼠中构建了一种行为分泌图，用于说明动物行为与血浆激素水平之间的相位关系。在采血前2天，将导管插入雄性大鼠的右心房。在Animex上自由活动的条件下，通过导管每5分钟单独监测一次血浆皮质酮水平，持续数小时，Animex可记录自发运动活动。结果表明，运动活动的爆发与血浆皮质酮水平的爆发在时间上相关，前者的峰值比激素峰值提前15分钟。关于运动活动的类型，进食和梳理毛发与随后的激素升高显著相关，而饮水则不然。在另一系列实验中，在禁食或禁水24或48小时的清醒大鼠中研究了进食和饮水对血浆皮质酮水平的影响。在这两种情况下，进食比饮水引起更明显的升高，尽管后者本身的运动活动计数增加得更急剧。得出的结论是，在行为分泌图中，特定类型的运动活动，如进食和梳理毛发，在自由活动条件下会引起血浆皮质酮的锁相升高。
