Aguggini G, Clement M G, Widdicombe J G
Q J Exp Physiol. 1987 Jan;72(1):95-104. doi: 10.1113/expphysiol.1987.sp003058.
Laryngeal airflow resistance was measured in anaesthetized pigs during stimulation of lung vagal reflexes by injection of phenylbiguanide and of capsaicin, before and during pulmonary microembolism due to intravenous injection of hardened red blood cells; the microembolism caused pulmonary hypertension. The Breuer-Hering reflex was also assessed before and after pulmonary microembolism. Phenylbiguanide and capsaicin caused apnoea followed by rapid shallow breathing, hypertension, bradycardia and laryngeal constriction in inspiration and expiration. Most of these effects were abolished by bilateral cervical vagotomy. Pulmonary microembolism caused only small changes in breathing pattern, mainly a decrease in inspiratory time. After microembolism the Breuer-Hering reflex was enhanced, and injections of phenylbiguanide and capsaicin caused longer apnoeas by a vagal reflex. The changes in pattern of breathing and in lung reflexes after lung microembolism and during the associated pulmonary hypertension are consistent with an enhancement of pulmonary stretch receptor activity in this condition, but do not indicate any important role for C fibre reflexes.
在麻醉猪中，于静脉注射硬化红细胞导致肺微栓塞之前及期间，通过注射苯乙双胍和辣椒素刺激肺迷走反射来测量喉气流阻力；该微栓塞导致了肺动脉高压。同时在肺微栓塞前后评估布雷尔 - 黑林反射。苯乙双胍和辣椒素引起呼吸暂停，随后是快速浅呼吸、高血压、心动过缓以及吸气和呼气时的喉收缩。这些效应大多可通过双侧颈迷走神经切断术消除。肺微栓塞仅引起呼吸模式的微小变化，主要是吸气时间缩短。微栓塞后布雷尔 - 黑林反射增强，注射苯乙双胍和辣椒素通过迷走反射导致更长时间的呼吸暂停。肺微栓塞后及相关肺动脉高压期间呼吸模式和肺反射的变化与这种情况下肺牵张感受器活性增强一致，但未表明C纤维反射有任何重要作用。
