Nakano Ryota, Shiomi Hideyuki, Fujiwara Aoi, Yoshihara Kohei, Yoshioka Ryota, Kawata Shoki, Ota Shogo, Yuri Yukihisa, Takashima Tomoyuki, Aizawa Nobuhiro, Ikeda Naoto, Nishimura Takashi, Enomoto Hirayuki, Iijima Hiroko
Division of Gastroenterology and Hepato-Biliary-Pancreatology, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Hyogo, Japan.
Healthcare (Basel). 2022 Apr 20;10(5):763. doi: 10.3390/healthcare10050763.
The indications for immune checkpoint inhibitors (ICIs) have expanded to include carcinomas of various organs. However, as ICI therapy expands, the management of immune-related adverse events (irAEs) has become a problem. ICI-related pancreatitis and cholangitis are relatively rare irAEs. Although some patients with ICI-related pancreatitis and cholangitis are asymptomatic and do not require treatment, there have been reports of patients who did not respond to immunosuppressive therapy and died. Thus, the pathogenesis of ICI-related pancreatitis and cholangitis should be clarified immediately. Currently, the role of endoscopy in the diagnosis and treatment of inflammatory pancreatic and biliary duct diseases is becoming increasingly important. In this review, we summarize clinical characteristics as well as radiographic and endoscopic findings of ICI-related pancreatitis and cholangitis.
免疫检查点抑制剂（ICI）的适应证已扩大到包括各种器官的癌。然而，随着ICI治疗的扩大，免疫相关不良事件（irAE）的管理已成为一个问题。ICI相关的胰腺炎和胆管炎是相对罕见的irAE。虽然一些患有ICI相关胰腺炎和胆管炎的患者无症状且无需治疗，但也有患者对免疫抑制治疗无反应并死亡的报道。因此，应立即阐明ICI相关胰腺炎和胆管炎的发病机制。目前，内镜检查在炎症性胰腺和胆管疾病的诊断和治疗中的作用越来越重要。在本综述中，我们总结了ICI相关胰腺炎和胆管炎的临床特征以及影像学和内镜检查结果。
