Chandwani Neelam, Dabhekar Sandeep, Selvi Kalai, Mohamed Roshan Noor, Abullais Shahabe Saquib, Moothedath Muhamood, Jadhav Ganesh, Chandwani Jaya, Karobari Mohmed Isaqali, Pawar Ajinkya M
Dentistry Department, All India Institute of Medical Sciences, Nagpur 441108, Maharashtra, India.
ENT Department, All India Institute of Medical Sciences, Nagpur 441108, Maharashtra, India.
Healthcare (Basel). 2022 May 13;10(5):912. doi: 10.3390/healthcare10050912.
The primary goal of this study was to assess the prevalence of oral involvement and, secondarily, the likely variables in patients with confirmed COVID-19 accompanied by mucormycosis infection. The study design was a cross-sectional descriptive sort that was performed at a tertiary centre. The non-probability convenience sampling approach was used to determine the sample size. Between May 2021 and July 2021, all patients who presented to our tertiary care centre with suspected mucormycosis were considered for the investigation. The research only included individuals with proven mucormycosis after COVID-19. The features of the patients, the frequency of intraoral signs/symptoms, and the possible variables were all noted. Of the 333 COVID-19-infected patients, 47 (14%) were diagnosed with confirmed mucormycosis. The mean (SD) age of the patients was 59.7 (11.9) years. Of the 47 patients with confirmed mucormycosis, 34% showed sudden tooth mobility, 34% expressed toothache, 8.5% reported palatal eschar, 34% presented with jaw pain, 8.5% had tongue discoloration, and 17% had temporomandibular pain. About 53% of the patients were known cases of type 2 diabetes mellitus, 89% of patients had a history of hospitalization due to COVID-19 infection, 89.3% underwent oxygen support therapy, and 89.3% were administered intravenous steroids during hospitalization due to COVID-19 infection. About 14% of the suspected cases attending the mucormycosis out-patient department (OPD) had been confirmed with definite mucormycosis. Oral involvement was seen in 45% of cases of CAM (COVID-associated mucormycosis). The most frequent oral symptoms presented in CAM were sudden tooth mobility and toothache. Diabetes and steroids were the likely contributing factors associated with CAM.
本研究的主要目标是评估口腔受累的患病率,其次是评估确诊为新型冠状病毒肺炎(COVID-19)并伴有毛霉菌病感染患者的可能相关变量。本研究采用横断面描述性研究设计,在一家三级中心进行。采用非概率方便抽样方法确定样本量。在2021年5月至2021年7月期间,所有因疑似毛霉菌病就诊于我们三级医疗中心的患者均被纳入调查。本研究仅纳入COVID-19后确诊为毛霉菌病的个体。记录了患者的特征、口腔体征/症状的发生频率以及可能的相关变量。在这333例COVID-19感染患者中,47例(14%)被确诊为毛霉菌病。患者的平均(标准差)年龄为59.7(11.9)岁。在这47例确诊为毛霉菌病的患者中,34%出现牙齿突然松动,34%表示牙痛,8.5%报告腭部焦痂,34%出现颌部疼痛,8.5%有舌变色,17%有颞下颌关节疼痛。约53%的患者为2型糖尿病已知病例,89%的患者有因COVID-19感染住院史,89.3%接受了氧疗,89.3%在因COVID-19感染住院期间接受了静脉注射类固醇治疗。在毛霉菌病门诊就诊的疑似病例中,约14%被确诊为毛霉菌病。45%的COVID-19相关毛霉菌病(CAM)病例出现口腔受累。CAM中最常见的口腔症状是牙齿突然松动和牙痛。糖尿病和类固醇可能是与CAM相关的因素。