Department of Oral Pathology and Microbiology, Saveetha Dental College and Hospitals, Chennai, Tamil Nadu, India; Department of Oral Pathology and Microbiology, Postgraduate Institute of Dental Sciences, Rohtak, Haryana, India.
Department of Oral Pathology and Microbiology, Postgraduate Institute of Dental Sciences, Rohtak, Haryana, India.
Med Hypotheses. 2021 Jul;152:110613. doi: 10.1016/j.mehy.2021.110613. Epub 2021 May 26.
Corona Virus Disease 2019 (COVID 2019), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a dreadful infectious disease which has emerged as one of the most significant medical emergency affecting everyone directly or indirectly. COVID 2019 is a multisystem disease and causes severe immunosuppression. Initially thought to affect mainly the respiratory system, it strikes all vital organ systems and cause defects in cardio-circulatory, respiratory system and gastrointestinal systems to name a few leading to copious biochemical alterations. Reports show there is thromoembolism, raised ferritin levels, lymphocytopenia, thrombocytopenia, lactic acidosis, acute diabetes like state and cytokine storm. Data regarding levels of neutrophils is equivocal. Further there is increased incidence regarding high incidents of mucormycosis in COVID 2019 positive subjects. In the present paper, we identified and correlated the virus mediated biochemical alterations as the potential ideal environment for propagation of mucorales; and thus concentrate on early diagnosis and treatment of mucormycosis in COVID 2019 cases.
2019 年冠状病毒病（COVID-19）由严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）引起，是一种可怕的传染病，直接或间接地影响着每个人，是目前最重大的医疗紧急事件之一。COVID-19 是一种多系统疾病，可导致严重的免疫抑制。最初被认为主要影响呼吸系统，它会影响所有重要的器官系统，并导致心血管系统、呼吸系统和胃肠道系统等方面的缺陷，从而导致大量的生化改变。有报道称存在血栓栓塞、铁蛋白水平升高、淋巴细胞减少症、血小板减少症、乳酸酸中毒、类似急性糖尿病状态和细胞因子风暴。关于中性粒细胞水平的数据尚无定论。此外，COVID-19 阳性患者中曲霉菌病的发生率也有所增加。在本文中，我们确定并关联了病毒介导的生化改变，认为其为毛霉菌属繁殖的理想环境；因此，我们专注于 COVID-19 病例中毛霉菌病的早期诊断和治疗。
