Department of Forensic Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Tokyo 113-8519, Japan.
Int J Mol Sci. 2022 May 12;23(10):5418. doi: 10.3390/ijms23105418.
The dynamic balance of mitochondrial fission and fusion maintains mitochondrial homeostasis and optimal function. It is indispensable for cells such as neurons, which rely on the finely tuned mitochondria to carry out their normal physiological activities. The potent psychostimulant cocaine impairs mitochondria as one way it exerts its neurotoxicity, wherein the disturbances in mitochondrial dynamics have been suggested to play an essential role. In this review, we summarize the neurotoxicity of cocaine and the role of mitochondrial dynamics in cellular physiology. Subsequently, we introduce current findings that link disturbed neuronal mitochondrial dynamics with cocaine exposure. Finally, the possible role and potential therapeutic value of mitochondrial dynamics in cocaine neurotoxicity are discussed.
线粒体分裂和融合的动态平衡维持着线粒体的内稳态和最佳功能。对于神经元等依赖精细调节的线粒体来进行正常生理活动的细胞来说，这是必不可少的。强效精神兴奋剂可卡因通过损害线粒体来发挥其神经毒性作用，其中线粒体动力学的紊乱被认为起着至关重要的作用。在这篇综述中，我们总结了可卡因的神经毒性作用以及线粒体动力学在细胞生理学中的作用。随后，我们介绍了目前将神经元线粒体动力学紊乱与可卡因暴露联系起来的研究发现。最后，讨论了线粒体动力学在可卡因神经毒性中的可能作用和潜在的治疗价值。
