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玻璃状金属氧化物颗粒嵌入微米厚的海藻酸盐薄膜中，有望成为有前途的伤口愈合纳米材料。

Glassy-like Metal Oxide Particles Embedded on Micrometer Thicker Alginate Films as Promising Wound Healing Nanomaterials.

机构信息

Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.

Euromed Research Center, Engineering Division, Euro-Med University of Fes (UEMF), Route de Meknes, Rond-Point de Bensouda, Fès 30070, Morocco.

出版信息

Int J Mol Sci. 2022 May 17;23(10):5585. doi: 10.3390/ijms23105585.

DOI:10.3390/ijms23105585
PMID:35628396
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9142123/
Abstract

Micrometer-thicker, biologically responsive nanocomposite films were prepared starting from alginate-metal alkoxide colloidal solution followed by sol-gel chemistry and solvent removal through evaporation-induced assembly. The disclosed approach is straightforward and highly versatile, allowing the entrapment and growth of a set of glassy-like metal oxide within the network of alginate and their shaping as crake-free transparent and flexible films. Immersing these films in aqueous medium triggers alginate solubilization, and affords water-soluble metal oxides wrapped in a biocompatible carbohydrate framework. Biological activity of the nano-composites films was also studied including their hemolytic activity, methemoglobin, prothrombin, and thrombine time. The effect of the films on fibroblasts and keratinocytes of human skin was also investigated with a special emphasis on the role played by the incorporated metal oxide. This comparative study sheds light on the crucial biological response of the ceramic phase embedded inside of the films, with titanium dioxide being the most promising for wound healing purposes.

摘要

从海藻酸盐-金属醇盐胶体溶液开始，通过溶胶-凝胶化学和蒸发诱导组装去除溶剂，制备了厚度达几微米、具有生物响应性的纳米复合薄膜。所公开的方法简单且非常通用，允许将一组玻璃状金属氧化物包埋在海藻酸盐网络中，并将其成型为无裂纹的透明和柔性薄膜。将这些薄膜浸入水介质中会触发海藻酸盐的溶解，并提供包裹在生物相容性碳水化合物框架中的水溶性金属氧化物。还研究了纳米复合材料薄膜的生物活性，包括其溶血活性、高铁血红蛋白、凝血酶原和凝血酶时间。还特别研究了薄膜对人皮肤成纤维细胞和角质细胞的影响，重点研究了掺入的金属氧化物所起的作用。这项比较研究揭示了嵌入薄膜内部的陶瓷相的关键生物学反应，其中二氧化钛最有希望用于伤口愈合。

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