靶向癌症中的 MAPK 2.0。
Targeting MAPK in Cancer 2.0.
机构信息
Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, 50134 Florence, Italy.
出版信息
Int J Mol Sci. 2022 May 20;23(10):5702. doi: 10.3390/ijms23105702.
Abstract
Mitogen-activated protein kinase (MAPK) pathways are prominently involved in the onset and progression of cancer [...].
摘要
有丝分裂原激活的蛋白激酶（MAPK）途径在癌症的发生和进展中起着重要作用[... ]。
相似文献
1
Targeting MAPK in Cancer 2.0.靶向癌症中的 MAPK 2.0。
Int J Mol Sci. 2022 May 20;23(10):5702. doi: 10.3390/ijms23105702.
2
Extracellular-signal-regulated kinase/mitogen-activated protein kinase signaling as a target for cancer therapy: an updated review.细胞外信号调节激酶/丝裂原活化蛋白激酶信号转导作为癌症治疗的靶点：更新综述。
Cell Biol Int. 2019 Nov;43(11):1206-1222. doi: 10.1002/cbin.11187. Epub 2019 Jul 11.
3
Mitogen-activated protein kinases and Hedgehog-GLI signaling in cancer: A crosstalk providing therapeutic opportunities?丝裂原活化蛋白激酶和 Hedgehog-GLI 信号通路在癌症中的作用：一种提供治疗机会的串扰？
Semin Cancer Biol. 2015 Dec;35:154-67. doi: 10.1016/j.semcancer.2015.08.003. Epub 2015 Aug 17.
4
Functional measurement of mitogen-activated protein kinase pathway activation predicts responsiveness of RAS-mutant cancers to MEK inhibitors.丝裂原活化蛋白激酶途径激活的功能测量可预测RAS突变癌症对MEK抑制剂的反应性。
Eur J Cancer. 2021 May;149:184-192. doi: 10.1016/j.ejca.2021.01.055. Epub 2021 Apr 14.
5
Modulation of sensitivity to antitumor agents by targeting the MAPK survival pathway.靶向 MAPK 生存通路调节抗肿瘤药物敏感性。
Curr Pharm Des. 2013;19(5):883-94.
6
Advances in targeting the Ras/Raf/MEK/Erk mitogen-activated protein kinase cascade with MEK inhibitors for cancer therapy.使用MEK抑制剂靶向Ras/Raf/MEK/Erk丝裂原活化蛋白激酶级联用于癌症治疗的进展。
Clin Cancer Res. 2008 Jan 15;14(2):342-6. doi: 10.1158/1078-0432.CCR-07-4790.
7
Acrolein activates mitogen-activated protein kinase signal transduction pathways in rat vascular smooth muscle cells.丙烯醛激活大鼠血管平滑肌细胞中的丝裂原活化蛋白激酶信号转导通路。
Mol Cell Biochem. 2002 Nov;240(1-2):83-98. doi: 10.1023/a:1020659808981.
8
Activation of the p38 and p42/p44 mitogen-activated protein kinase families by the histamine H(1) receptor in DDT(1)MF-2 cells.组胺H(1)受体在DDT(1)MF-2细胞中对p38和p42/p44丝裂原活化蛋白激酶家族的激活作用。
Br J Pharmacol. 2001 Aug;133(8):1378-86. doi: 10.1038/sj.bjp.0704200.
9
Compensation of Adiponectin-Induced Adenosine Monophosphate-Activated Protein Kinase and p38 Mitogen-Activated Protein Kinase Signaling in Rheumatoid Arthritis Synovial Fibroblasts.脂联素诱导的腺苷一磷酸激活蛋白激酶和 p38 丝裂原活化蛋白激酶信号在类风湿关节炎滑膜成纤维细胞中的补偿作用。
J Interferon Cytokine Res. 2021 May;41(5):177-186. doi: 10.1089/jir.2019.0204.
10
MAP kinase signalling pathways in cancer.癌症中的丝裂原活化蛋白激酶信号通路。
Oncogene. 2007 May 14;26(22):3279-90. doi: 10.1038/sj.onc.1210421.
引用本文的文献
1
Physical Activity and Cancer Incidence and Mortality: Current Evidence and Biological Mechanisms.体力活动与癌症发病率和死亡率：当前证据及生物学机制
Cancers (Basel). 2025 Apr 23;17(9):1410. doi: 10.3390/cancers17091410.
2
Natural Products as Novel Therapeutic Agents for Triple-Negative Breast Cancer: Current Evidence, Mechanisms, Challenges, and Opportunities.天然产物作为三阴性乳腺癌的新型治疗药物：当前证据、作用机制、挑战与机遇
Molecules. 2025 Mar 7;30(6):1201. doi: 10.3390/molecules30061201.
3
Kappa opioid receptor internalisation-induced p38 nuclear translocation suppresses glioma progression.κ阿片受体内化诱导的p38核转位抑制胶质瘤进展。
Br J Anaesth. 2025 Mar;134(3):759-771. doi: 10.1016/j.bja.2024.09.031. Epub 2024 Dec 30.
4
The dysregulation of PARP9 expression is linked to apoptosis and DNA damage in gastric cancer cells.PARP9表达失调与胃癌细胞的凋亡和DNA损伤有关。
PLoS One. 2024 Dec 31;19(12):e0316476. doi: 10.1371/journal.pone.0316476. eCollection 2024.
5
Unveiling the role of PYGB in pancreatic cancer: a novel diagnostic biomarker and gene therapy target.揭示 PYGB 在胰腺癌中的作用：一种新的诊断生物标志物和基因治疗靶点。
J Cancer Res Clin Oncol. 2024 Mar 14;150(3):127. doi: 10.1007/s00432-024-05644-2.
6
Emerging Therapies in Management of Cholangiocarcinoma.胆管癌治疗的新兴疗法
Cancers (Basel). 2024 Jan 31;16(3):613. doi: 10.3390/cancers16030613.
7
FABP6 serves as a new therapeutic target in esophageal tumor.脂肪酸结合蛋白6（FABP6）作为食管肿瘤的一个新的治疗靶点。
Aging (Albany NY). 2024 Jan 25;16(2):1640-1662. doi: 10.18632/aging.205448.
8
Effect of traditional Chinese medicine in osteosarcoma: Cross-interference of signaling pathways and potential therapeutic targets.中药在骨肉瘤中的作用：信号通路的交叉干扰和潜在的治疗靶点。
Medicine (Baltimore). 2024 Jan 19;103(3):e36467. doi: 10.1097/MD.0000000000036467.
9
Investigating the effect of gene (MEK1) in MAPK pathway in the induction of adult T-cell leukemia/lymphoma (ATLL).研究丝裂原活化蛋白激酶（MAPK）信号通路中的基因（MEK1）在成人T细胞白血病/淋巴瘤（ATLL）诱导中的作用。
Iran J Microbiol. 2023 Jun;15(3):475-481. doi: 10.18502/ijm.v15i3.12910.
10
Design, Synthesis and Biological Evaluation of 6-(Imidazo[1,2-a]pyridin-6-yl)quinazoline Derivatives as Anticancer Agents via PI3Kα Inhibition.通过抑制 PI3Kα，设计、合成并评估 6-(咪唑并[1,2-a]吡啶-6-基)喹唑啉衍生物作为抗癌剂。
Int J Mol Sci. 2023 Apr 6;24(7):6851. doi: 10.3390/ijms24076851.
本文引用的文献
1
Clinical Translation of Combined MAPK and Autophagy Inhibition in Mutant Cancer.联合 MAPK 和自噬抑制在突变癌症中的临床转化。
Int J Mol Sci. 2021 Nov 17;22(22):12402. doi: 10.3390/ijms222212402.
2
The Hedgehog-GLI Pathway Regulates MEK5-ERK5 Expression and Activation in Melanoma Cells.刺猬蛋白-GLI 通路调控黑素瘤细胞中 MEK5-ERK5 的表达和激活。
Int J Mol Sci. 2021 Oct 19;22(20):11259. doi: 10.3390/ijms222011259.
3
Iron Chelator Induces Apoptosis in Osteosarcoma Cells by Disrupting Intracellular Iron Homeostasis and Activating the MAPK Pathway.铁螯合剂通过破坏细胞内铁稳态和激活 MAPK 通路诱导骨肉瘤细胞凋亡。
Int J Mol Sci. 2021 Jul 2;22(13):7168. doi: 10.3390/ijms22137168.
4
Playing the Whack-A-Mole Game: ERK5 Activation Emerges Among the Resistance Mechanisms to RAF-MEK1/2-ERK1/2- Targeted Therapy.玩打地鼠游戏：ERK5激活成为RAF-MEK1/2-ERK1/2靶向治疗耐药机制之一。
Front Cell Dev Biol. 2021 Mar 11;9:647311. doi: 10.3389/fcell.2021.647311. eCollection 2021.
5
Prevention of Melanoma Extravasation as a New Treatment Option Exemplified by p38/MK2 Inhibition.以 p38/MK2 抑制为例探讨黑素瘤外渗的防治新策略。
Int J Mol Sci. 2020 Nov 6;21(21):8344. doi: 10.3390/ijms21218344.
6
Horizontal Combination of MEK and PI3K/mTOR Inhibition in BRAF Mutant Tumor Cells with or without Concomitant PI3K Pathway Mutations.BRAF 突变型肿瘤细胞中 MEK 和 PI3K/mTOR 抑制的水平联合抑制，有无同时存在的 PI3K 通路突变。
Int J Mol Sci. 2020 Oct 16;21(20):7649. doi: 10.3390/ijms21207649.
7
Targeting ERK-Hippo Interplay in Cancer Therapy.靶向 ERK-Hippo 相互作用的癌症治疗。
Int J Mol Sci. 2020 May 3;21(9):3236. doi: 10.3390/ijms21093236.
8
MAP Kinases Pathways in Gastric Cancer.胃癌中的 MAP 激酶途径。
Int J Mol Sci. 2020 Apr 21;21(8):2893. doi: 10.3390/ijms21082893.
9
The p38 MAPK Signaling Activation in Colorectal Cancer upon Therapeutic Treatments.结直肠癌治疗后 p38 MAPK 信号通路的激活。
Int J Mol Sci. 2020 Apr 16;21(8):2773. doi: 10.3390/ijms21082773.
10
Current Insights into Combination Therapies with MAPK Inhibitors and Immune Checkpoint Blockade.当前对 MAPK 抑制剂和免疫检查点阻断联合治疗的深入了解。
Int J Mol Sci. 2020 Apr 5;21(7):2531. doi: 10.3390/ijms21072531.
Zotero 插件