• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

上皮-间质转化（EMT）2021。

Epithelial-Mesenchymal Transition (EMT) 2021.

机构信息

Department of Life Sciences, University of Trieste, 34127 Trieste, Italy.

National Research Council (CNR), Institute of Experimental Endocrinology and Oncology (IEOS), 80145 Naples, Italy.

出版信息

Int J Mol Sci. 2022 May 23;23(10):5848. doi: 10.3390/ijms23105848.

DOI:10.3390/ijms23105848
PMID:35628655
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9145979/
Abstract

Epithelial-mesenchymal transition (EMT) is a transdifferentiation process wherein epithelial cells acquire characteristics typical of mesenchymal cells [...].

摘要

上皮-间充质转化（EMT）是一种细胞转分化过程，在此过程中上皮细胞获得了间充质细胞的典型特征[...]。

相似文献

1
Epithelial-Mesenchymal Transition (EMT) 2021.上皮-间质转化（EMT）2021。
Int J Mol Sci. 2022 May 23;23(10):5848. doi: 10.3390/ijms23105848.
2
Epithelial-mesenchymal transition and the stem cell phenotype.上皮-间质转化与干细胞表型
Cell Stem Cell. 2008 Jun 5;2(6):511-2. doi: 10.1016/j.stem.2008.05.007.
3
Epithelial-mesenchymal transition in cancer: parallels between normal development and tumor progression.上皮-间充质转化在癌症中的作用：正常发育和肿瘤进展之间的相似性。
J Mammary Gland Biol Neoplasia. 2010 Jun;15(2):117-34. doi: 10.1007/s10911-010-9178-9. Epub 2010 May 19.
4
Epithelial-mesenchymal transition (EMT) in tumor-initiating cells and its clinical implications in breast cancer.肿瘤起始细胞中的上皮-间充质转化及其在乳腺癌中的临床意义。
J Mammary Gland Biol Neoplasia. 2010 Jun;15(2):253-60. doi: 10.1007/s10911-010-9173-1. Epub 2010 Mar 31.
5
TGF-beta-induced epithelial to mesenchymal transition.转化生长因子-β诱导的上皮-间质转化
Cell Res. 2009 Feb;19(2):156-72. doi: 10.1038/cr.2009.5.
6
Snail family regulation and epithelial mesenchymal transitions in breast cancer progression.蜗牛家族调控与乳腺癌进展中的上皮间质转化。
J Mammary Gland Biol Neoplasia. 2010 Jun;15(2):135-47. doi: 10.1007/s10911-010-9179-8. Epub 2010 May 9.
7
Cell polarity in motion: redefining mammary tissue organization through EMT and cell polarity transitions.细胞运动中的极性：通过 EMT 和细胞极性转变重新定义乳腺组织的结构。
J Mammary Gland Biol Neoplasia. 2010 Jun;15(2):149-68. doi: 10.1007/s10911-010-9180-2. Epub 2010 May 12.
8
Epithelial-to-mesenchymal transitions and circulating tumor cells.上皮-间充质转化与循环肿瘤细胞。
J Mammary Gland Biol Neoplasia. 2010 Jun;15(2):261-73. doi: 10.1007/s10911-010-9174-0. Epub 2010 May 7.
9
Cellular Changes Consistent With Epithelial-Mesenchymal Transition and Fibroblast-to-Myofibroblast Transdifferentiation in the Progression of Experimental Endometriosis in Baboons.狒狒实验性子宫内膜异位症进展过程中与上皮-间质转化和成纤维细胞向肌成纤维细胞转分化一致的细胞变化。
Reprod Sci. 2016 Oct;23(10):1409-21. doi: 10.1177/1933719116641763. Epub 2016 Apr 12.
10
[Roles of macrophage-mediated epithelial mesenchymal transdifferentiation in fibrotic diseases].[巨噬细胞介导的上皮-间质转化在纤维化疾病中的作用]
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2018 Jan;30(1):91-93. doi: 10.3760/cma.j.issn.2095-4352.2018.01.018.

引用本文的文献

1
ADAMTS2 mediates epithelial‒mesenchymal transition and inflammation in high-grade serous ovarian cancer: a study based on bioinformatic analyses and experiments.ADAMTS2介导高级别浆液性卵巢癌的上皮-间质转化和炎症反应：一项基于生物信息学分析和实验的研究
BMC Cancer. 2025 Aug 26;25(1):1376. doi: 10.1186/s12885-025-14649-0.
2
Research progress on the role of the NEIL family in cancer.NEIL家族在癌症中作用的研究进展
Front Cell Dev Biol. 2025 Jul 21;13:1612329. doi: 10.3389/fcell.2025.1612329. eCollection 2025.
3
RUNX2 mediated epithelial mesenchymal transition induced by TGF beta and Smad signaling promotes malignant progression in glioma.RUNX2介导的由转化生长因子β和Smad信号传导诱导的上皮-间质转化促进胶质瘤的恶性进展。
Sci Rep. 2025 Jul 23;15(1):26781. doi: 10.1038/s41598-025-09167-9.
4
The regulatory network of epithelial-mesenchymal transition-associated non-coding RNAs in thyroid cancer: molecular mechanisms, clinical implications, and therapeutic strategies.甲状腺癌中上皮-间质转化相关非编码RNA的调控网络：分子机制、临床意义及治疗策略
Front Oncol. 2025 Jun 2;15:1592467. doi: 10.3389/fonc.2025.1592467. eCollection 2025.
5
Epithelial-mesenchymal transition (EMT) and its role in acquired epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) chemoresistance in non-small cell lung cancer (NSCLC).上皮-间质转化（EMT）及其在非小细胞肺癌（NSCLC）获得性表皮生长因子受体-酪氨酸激酶抑制剂（EGFR-TKI）化疗耐药中的作用。
Cancer Pathog Ther. 2024 Jul 6;3(3):215-225. doi: 10.1016/j.cpt.2024.07.001. eCollection 2025 May.
6
Downregulation of CPT2 promotes proliferation and migration through the TNFα/NF-κB pathway in cholangiocarcinoma.CPT2的下调通过肿瘤坏死因子α/核因子κB途径促进胆管癌的增殖和迁移。
J Gastrointest Oncol. 2025 Apr 30;16(2):679-698. doi: 10.21037/jgo-24-685. Epub 2025 Apr 27.
7
The clinical significance and potential therapeutic target of tumor-associated macrophage in non-small cell lung cancer.肿瘤相关巨噬细胞在非小细胞肺癌中的临床意义及潜在治疗靶点
Front Med (Lausanne). 2025 Apr 30;12:1541104. doi: 10.3389/fmed.2025.1541104. eCollection 2025.
8
The role and clinical significance of tumor-associated macrophages in the epithelial-mesenchymal transition of lung cancer.肿瘤相关巨噬细胞在肺癌上皮-间质转化中的作用及临床意义
Front Oncol. 2025 Apr 15;15:1571583. doi: 10.3389/fonc.2025.1571583. eCollection 2025.
9
Consensus nonnegative matrix factorization reveals metastatic gene expression program and identifies E74-like ETS transcription factor 3 confers to the lymph nodes metastasis in papillary thyroid cancer.共识非负矩阵分解揭示转移基因表达程序，并鉴定E74样ETS转录因子3赋予甲状腺乳头状癌淋巴结转移能力。
Endocrine. 2025 Jun;88(3):798-819. doi: 10.1007/s12020-025-04205-y. Epub 2025 Mar 6.
10
N-glycosylation of GSTO1 promotes cervical cancer migration and invasion through JAK/STAT3 pathway activation.GSTO1的N-糖基化通过激活JAK/STAT3信号通路促进宫颈癌的迁移和侵袭。
Funct Integr Genomics. 2025 Mar 3;25(1):51. doi: 10.1007/s10142-025-01565-6.

本文引用的文献

1
SYNCRIP Modulates the Epithelial-Mesenchymal Transition in Hepatocytes and HCC Cells.SYNCRIP 调控肝细胞和 HCC 细胞中的上皮-间充质转化。
Int J Mol Sci. 2022 Jan 14;23(2):913. doi: 10.3390/ijms23020913.
2
The Epithelial-Mesenchymal Transition at the Crossroads between Metabolism and Tumor Progression.上皮-间充质转化在代谢与肿瘤进展的交汇点。
Int J Mol Sci. 2022 Jan 12;23(2):800. doi: 10.3390/ijms23020800.
3
Distinct contributions of partial and full EMT to breast cancer malignancy.部分 EMT 和完全 EMT 对乳腺癌恶性程度的不同贡献。
Dev Cell. 2021 Dec 6;56(23):3203-3221.e11. doi: 10.1016/j.devcel.2021.11.006. Epub 2021 Nov 29.
4
Investigation of the Epithelial to Mesenchymal Transition (EMT) Process in Equine Papillomavirus-2 (EcPV-2)-Positive Penile Squamous Cell Carcinomas.研究马乳头瘤病毒 2 型（EcPV-2）阳性阴茎鳞状细胞癌中的上皮间质转化（EMT）过程。
Int J Mol Sci. 2021 Sep 30;22(19):10588. doi: 10.3390/ijms221910588.
5
Developmental chromatin programs determine oncogenic competence in melanoma.发育中的染色质程序决定黑色素瘤中的致癌能力。
Science. 2021 Sep 3;373(6559):eabc1048. doi: 10.1126/science.abc1048.
6
Reprogramming of bivalent chromatin states in NRAS mutant melanoma suggests PRC2 inhibition as a therapeutic strategy.NRAS 突变型黑色素瘤中双价染色质状态的重编程表明抑制 PRC2 可作为一种治疗策略。
Cell Rep. 2021 Jul 20;36(3):109410. doi: 10.1016/j.celrep.2021.109410.
7
Lung Cancer Models Reveal Severe Acute Respiratory Syndrome Coronavirus 2-Induced Epithelial-to-Mesenchymal Transition Contributes to Coronavirus Disease 2019 Pathophysiology.肺癌模型揭示严重急性呼吸综合征冠状病毒 2 诱导的上皮间质转化导致 2019 年冠状病毒病发病机制。
J Thorac Oncol. 2021 Nov;16(11):1821-1839. doi: 10.1016/j.jtho.2021.07.002. Epub 2021 Jul 16.
8
Expression of the E5 Oncoprotein of HPV16 Impacts on the Molecular Profiles of EMT-Related and Differentiation Genes in Ectocervical Low-Grade Lesions.HPV16 的 E5 癌蛋白的表达影响宫颈低级别病变中 EMT 相关和分化基因的分子谱。
Int J Mol Sci. 2021 Jun 18;22(12):6534. doi: 10.3390/ijms22126534.
9
Single-cell lineage tracing of metastatic cancer reveals selection of hybrid EMT states.单细胞谱系追踪转移性癌症揭示了杂交 EMT 状态的选择。
Cancer Cell. 2021 Aug 9;39(8):1150-1162.e9. doi: 10.1016/j.ccell.2021.05.005. Epub 2021 Jun 10.
10
Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma.癌细胞与免疫细胞的相互作用促使胶质母细胞瘤向间充质样状态转变。
Cancer Cell. 2021 Jun 14;39(6):779-792.e11. doi: 10.1016/j.ccell.2021.05.002. Epub 2021 Jun 3.