Krakhecke-Teixeira Alessandra G, Yamauchi Danielle H, Rossi Alexsandra, de Sousa Herdson R, Garces Hans G, Júnior Joaquim L, Júnior Antônio O S, Felipe Maria Sueli S, Bagagli Eduardo, de Andrade Heitor F, Teixeira Marcus de M
Tocantins Department of Public Health, Palmas 77015-007, TO, Brazil.
Institute of Tropical Medicine, University of São Paulo, São Paulo 05403-000, SP, Brazil.
J Fungi (Basel). 2022 May 12;8(5):502. doi: 10.3390/jof8050502.
Paracoccidioidomycosis (PCM) is the most prevalent systemic mycosis in Brazil. The disease is caused by dimorphic fungi nested within the Paracoccidioides genus. We described 106 PCM cases (47.1 cases/year) at the Tropical Diseases Public Hospital of Tocantins State. PCM was prevalent in males and rural workers over 50 years; the chronic pulmonary form predominated in 67% of cases. The male-to-female ratio was 2.65:1, with more women affected than other endemic regions of Brazil. Urban or indoor activities were reported in women and are ascribed to disease urbanization. qPCR-based assays confirmed the identification of Paracoccidioides DNA in 37 biological specimens. Paracoccidioides sp. DNA was found in 53% of the environmental samples, suggesting autochthonous infections. Therefore, the Tocantins-Araguaia basin must be considered a novel hyperendemic area of PCM in Brazil, reinforcing the importance of including PCM as a notifiable disease, requiring specific diagnosis and health measures.
副球孢子菌病（PCM）是巴西最常见的系统性真菌病。该病由副球孢子菌属内的双相真菌引起。我们在托坎廷斯州热带病公立医院描述了106例PCM病例（每年47.1例）。PCM在50岁以上的男性和农村工人中较为普遍；67%的病例以慢性肺型为主。男女比例为2.65:1，受影响的女性比巴西其他流行地区更多。女性报告有城市或室内活动，这归因于疾病的城市化。基于qPCR的检测在37份生物标本中证实了副球孢子菌DNA的鉴定。在53%的环境样本中发现了副球孢子菌属DNA，提示存在本地感染。因此，托坎廷斯-阿拉瓜亚盆地必须被视为巴西一个新的PCM高度流行地区，这强化了将PCM列为应报告疾病的重要性，需要进行特定诊断和采取健康措施。
