Ventura Patrizia, de Giambattista Concetta, Trerotoli Paolo, Cavone Maddalena, Di Gioia Alessandra, Margari Lucia
Child Neuropsychiatric Unit, University of Bari Aldo Moro, Piazza Giulio Cesare, 70121 Bari, Italy.
Department of Biomedical Sciences and Human Oncology, University of Bari, 70010 Bari, Italy.
J Clin Med. 2022 May 22;11(10):2922. doi: 10.3390/jcm11102922.
Emotional dysregulation (ED) is common in attention-deficit/hyperactivity disorder (ADHD). Nonetheless, research on ADHD in children with autism spectrum disorder (ASD) and ADHD is still ongoing. Several studies suggest that methylphenidate (MPH) may be effective for ED in ADHD, while there is not enough evidence about its use in ASD with comorbid ADHD. This naturalistic study aims to investigate the effectiveness of immediate- and extended-release MPH in the treatment of ED in 70 children and adolescents (6-18 years), with a diagnosis of ADHD ( = 41) and of ASD with comorbid ADHD ( = 29), using the Child Behavior Checklist-Attention/Aggressive/Anxious (CBCL-AAA). Their parents completed the CBCL twice-first during the summer medication-free period, that is, at least one month after drug interruption; and again after three months of treatment restart. Results demonstrate that MPH is associated with a statistically significant reduction in ED in ADHD and ASD, without substantial adverse events, supporting the use of psychostimulants for the treatment of ED in these neurodevelopmental disorders.
情绪调节障碍（ED）在注意力缺陷多动障碍（ADHD）中很常见。尽管如此，关于自闭症谱系障碍（ASD）合并ADHD儿童的ADHD研究仍在进行中。多项研究表明，哌甲酯（MPH）可能对ADHD中的ED有效，而关于其在合并ADHD的ASD中的应用证据不足。这项自然主义研究旨在使用儿童行为清单 - 注意力/攻击/焦虑量表（CBCL - AAA），调查速释和缓释MPH对70名6至18岁诊断为ADHD（n = 41）和合并ADHD的ASD（n = 29）儿童和青少年ED的治疗效果。他们的父母在夏季无药期（即停药至少一个月后）和重新开始治疗三个月后，两次完成CBCL。结果表明，MPH与ADHD和ASD中ED的统计学显著降低相关，且无重大不良事件，支持在这些神经发育障碍中使用精神兴奋剂治疗ED。
