Damaskos Christos, Garmpis Nikolaos, Dimitroulis Dimitrios, Garmpi Anna, Diamantis Evangelos, Sarantis Panagiotis, Georgakopoulou Vasiliki E, Patsouras Alexandros, Despotidis Markos, Prevezanos Dionysios, Syllaios Athanasios, Marinos Georgios, Koustas Evangelos, Vallilas Christos, Antoniou Efstathios A, Kontzoglou Konstantinos, Savvanis Spyridon, Kouraklis Gregory
Renal Transplantation Unit, Laiko General Hospital, 11527 Athens, Greece.
N.S. Christeas Laboratory of Experimental Surgery and Surgical Research, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
J Pers Med. 2022 May 6;12(5):753. doi: 10.3390/jpm12050753.
Long non-coding RNAs (lncRNAs) are transcripts of more than 200 nucleotides which cannot be translated into proteins. Small nucleolar RNA host gene 15 (SNHG15) is a lncRNA whose dysregulation has been found to have an important impact on carcinogenesis and affect the prognosis of cancer patients in various cancer types. Hepatocellular carcinoma (HCC) is one of the most common cancers with a poor long-term prognosis, while the best prognostic factor of the disease is its early diagnosis and surgery. Consequently, the investigation of the mechanisms of hepatocarcinogenesis, as well as the discovery of efficient molecular markers and therapeutic targets are of great significance. An extensive literature search was performed in MEDLINE in order to identify clinical studies that tried to reveal the role of SNHG15 in HCC. We used keywords such as 'HCC', 'hepatocellular carcinoma', 'SNHG15' and 'clinical study'. Finally, we included four studies written in English, published during the period 2016-2021. It was revealed that SNHG15 is related to the appearance of HCC via different routes and its over-expression affects the overall survival of the patients. More assays are required in order to clarify the potential role of SNHG15 as a prognostic tool and therapeutic target in HCC.
长链非编码RNA（lncRNAs）是一类长度超过200个核苷酸且不能翻译成蛋白质的转录本。小核仁RNA宿主基因15（SNHG15）是一种lncRNA，其失调已被发现对癌症发生具有重要影响，并影响各种癌症类型患者的预后。肝细胞癌（HCC）是最常见的癌症之一，长期预后较差，而该疾病的最佳预后因素是早期诊断和手术。因此，研究肝癌发生机制以及发现有效的分子标志物和治疗靶点具有重要意义。为了确定试图揭示SNHG15在HCC中作用的临床研究，我们在MEDLINE中进行了广泛的文献检索。我们使用了“HCC”、“肝细胞癌”、“SNHG15”和“临床研究”等关键词。最后，我们纳入了4篇2016年至2021年期间发表的英文研究。结果显示，SNHG15通过不同途径与HCC的发生相关，其过表达影响患者的总生存期。为了阐明SNHG15作为HCC预后工具和治疗靶点的潜在作用，还需要更多的检测。
