Obstetrics and Gynecology Unit, Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Medicina (Kaunas). 2022 May 9;58(5):646. doi: 10.3390/medicina58050646.
: and purpurea have known immunomodulatory effects which boost viral clearance, including HPV infection. However, evidence regarding the improvement due to Echinacea-based supplements of cervical HPV-related pathologies is still lacking. The aim of this study is to evaluate the efficacy of Echinacea supplementation on the remission of cervical low-grade squamous intraepithelial lesions (L-SIL). : A single-blind 1:1:1 parallel randomized controlled trial was conducted at the Colposcopy Unit of a tertiary care referral center. Reproductive-aged women were allocated either to (a) an oral supplement based on Echinacea extracts plus vaginal hyaluronic acid-based soft gel capsules, (b) the Echinacea supplement alone, or (c) vaginal hyaluronic acid-based soft gel capsules alone for 3 months. The primary outcome was the regression of cervical intraepithelial neoplasia (CIN)-1 for each treatment arm at 3, 6 and 12 months after the diagnosis. Secondary outcomes included changes in the epithelialization, pap smear, colposcopic parameters, histological reports, and vaginal health indexes (VHI) in the study groups. : 153 women (52 for arm A, 50 for arm B and 51 for arm C) completed the follow-up and were included in the analysis. There were no significant differences in both primary and secondary outcomes for the three groups after 3 months. At the 6-month follow-up, the number of persistent CIN-1 diagnoses was significantly lower in arm A (15/51), rather than in arm B (23/48, = 0.03) and C (27/49, = 0.03). Similarly, the same effect was seen after 12 months for treatment A (5/51) relative to B (15/48, = 0.03) and C (14/48, = 0.03). Colposcopic, histological and vaginal parameters were all significantly improved at 6 and 12 months for arm A relative to B and C, while no beneficial effects were seen after 3 months. : Echinacea extracts supplementation in women with L-SIL/CIN-1 significantly boosts HPV lesion clearance, reducing the overall amount of diagnosis, histological, colposcopic and vaginal parameters after 6 and 12 months. However, a limited sample size reduces the quality of evaluated evidence, emphasizing the need for additional studies to validate these findings.
紫锥菊和 purpurea 具有免疫调节作用，可促进病毒清除，包括 HPV 感染。然而，关于基于紫锥菊的补充剂改善宫颈 HPV 相关病变的证据仍然缺乏。本研究旨在评估紫锥菊补充剂对缓解宫颈低级别鳞状上皮内病变（L-SIL）的疗效。
一项在三级转诊中心阴道镜科进行的单盲 1:1:1 平行随机对照试验。将育龄妇女分为（a）口服紫锥菊提取物加阴道透明质酸软凝胶胶囊的补充剂，（b）紫锥菊补充剂单独，或（c）阴道透明质酸软凝胶胶囊单独治疗 3 个月。主要结局是在诊断后 3、6 和 12 个月时，每个治疗组宫颈上皮内瘤变（CIN）-1 的消退情况。次要结局包括研究组上皮化、巴氏涂片、阴道镜参数、组织学报告和阴道健康指数（VHI）的变化。
153 名女性（A 组 52 名，B 组 50 名，C 组 51 名）完成了随访并纳入分析。三组治疗后 3 个月时，主要和次要结局均无显著差异。在 6 个月的随访中，A 组（15/51）持续性 CIN-1 诊断的数量明显低于 B 组（23/48， = 0.03）和 C 组（27/49， = 0.03）。同样，A 组在 12 个月时也观察到相同的效果（5/51 与 B 组（15/48， = 0.03）和 C 组（14/48， = 0.03）。与 B 组和 C 组相比，A 组在 6 个月和 12 个月时阴道镜、组织学和阴道参数均显著改善，而在 3 个月时未见有益效果。
在 L-SIL/CIN-1 妇女中补充紫锥菊提取物可显著促进 HPV 病变清除，减少 6 个月和 12 个月时的总体诊断、组织学、阴道镜和阴道参数。然而，样本量有限降低了评估证据的质量，强调需要进一步研究来验证这些发现。
