Grandi Giovanni, Botticelli Laura, Fraia Pietro Di, Babalini Carla, Masini Meris, Unfer Vittorio
Department of Medical and Surgical Sciences for Mother, Child and Adult, Obstetrics and Gynecology Unit, University of Modena and Reggio Emilia, Azienda Ospedaliero Universitaria Policlinico, 41125 Modena, Italy.
Department of Pathology, Azienda Ospedaliero Universitaria Policlinico, University of Modena and Reggio Emilia, 41125 Modena, Italy.
J Pers Med. 2023 Mar 22;13(3):567. doi: 10.3390/jpm13030567.
Precancerous lesions of the uterine cervix, due to HPV infections, are still today a great medical challenge. This clinical case highlighted the effectiveness of epigallocatechin gallate (EGCG), vitamin B12, folic acid, and hyaluronic acid (HA) in counteracting HPV lesions in a 39-year-old patient with a long history of viral persistence, cervical lesions of various degree, and several unsuccessful surgical approaches. After eight weeks of treatment, both the histological and cytological analyses revealed only a chronic cervicitis without any malignant lesions or cellular dysplasia, thus reducing the urgency of an invasive surgery, a total hysterectomy.
由于人乳头瘤病毒（HPV）感染导致的子宫颈癌前病变，至今仍是一项重大的医学挑战。本临床病例突出了表没食子儿茶素没食子酸酯（EGCG）、维生素B12、叶酸和透明质酸（HA）在一名39岁患者中对抗HPV病变的有效性，该患者有长期病毒持续感染史、不同程度的宫颈病变以及多次手术治疗失败。经过八周的治疗，组织学和细胞学分析均显示仅为慢性宫颈炎，无任何恶性病变或细胞发育异常，从而降低了进行侵入性手术（全子宫切除术）的紧迫性。
