Hospital of Psychiatry "Elisabeta Doamna", 290 Traian Street, 800179 Galați, Romania.
Clinical Medical Department, Faculty of Medicine and Pharmacy, University "Dunărea de Jos", 47 Domnească Street, 800008 Galați, Romania.
Medicina (Kaunas). 2022 May 11;58(5):652. doi: 10.3390/medicina58050652.
Over time, studies have shown the importance of determining serotonin levels to diagnose somatic and psychiatric disorders. There are theoretical premises and practical ways to achieve a subtle correlation between the existence of comorbid psychiatric disorders and somatic diseases caused by the changes observed in serotonin levels. The present study, classified as retrospective and quantitative, provides evidence for determining the serotonin levels in patients with diabetes and anxiety or depression. A total of 48 patients with diabetes type 2 were enrolled in the study. Blood glucose level, glycated haemoglobin, and serum serotonin were noted, and they completed Hamilton A and Beck Depression Inventory questionnaires. We found robust correlations between serum serotonin and blood glucose (Sig. = 0.008), serum serotonin and HbA1c (Sig. = 0.007), serum serotonin and anxiety (Sig. = 0.000), and serum serotonin and depression (Sig. = 0.000). It is also noteworthy that women recorded extreme values higher than men for glycated haemoglobin (95% confidence interval: 6.92-7.79 in women and 6.30-7.23 in men). In conclusion, using serotonin as a marker of the mentioned diseases in clinical practice is of significant utility, considering the benefits in terms of the evolution and prognosis of comorbidities in patients with type 2 diabetes and anxiety and depressive symptoms.
随着时间的推移，研究表明确定血清素水平对于诊断躯体和精神障碍非常重要。有理论前提和实际方法可以实现共存的精神障碍和由血清素水平变化引起的躯体疾病之间的微妙相关性。本研究被归类为回顾性和定量研究，为确定 2 型糖尿病伴焦虑或抑郁患者的血清素水平提供了证据。共有 48 名 2 型糖尿病患者入组本研究。记录了血糖水平、糖化血红蛋白和血清素水平，他们还完成了汉密尔顿焦虑量表 A 项和贝克抑郁量表问卷。我们发现血清素与血糖之间存在显著相关性（Sig. = 0.008），血清素与糖化血红蛋白之间存在显著相关性（Sig. = 0.007），血清素与焦虑之间存在显著相关性（Sig. = 0.000），血清素与抑郁之间存在显著相关性（Sig. = 0.000）。同样值得注意的是，女性的糖化血红蛋白值明显高于男性（女性的 95%置信区间为 6.92-7.79，男性为 6.30-7.23）。总之，在临床实践中使用血清素作为所提到疾病的标志物具有重要的实用价值，因为这有助于了解 2 型糖尿病患者伴发焦虑和抑郁症状时共病的演变和预后。
