Mo Jingshan, Liu Junqing, Huang Shuang, Liang Baoming, Huang Xinshuo, Yang Cheng, Chen Meiwan, Liu Jing, Zhang Tong, Xie Xi, Guo Jun, Liu Fanmao, Chen Hui-Jiuan
School of Electronics and Information Technology, State Key Laboratory of Optoelectronic Materials and Technologies, Guangdong Province Key Laboratory of Display Material and Technology, Sun Yat-Sen University, Guangzhou 510006, China.
Department of Cardiology, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
Micromachines (Basel). 2022 Apr 30;13(5):718. doi: 10.3390/mi13050718.
Microneedle systems have been widely used in health monitoring, painless drug delivery, and medical cosmetology. Although many studies on microneedle materials, structures, and applications have been conducted, the applications of microneedles often suffered from issues of inconsistent penetration rates due to the complication of skin-microneedle interface. In this study, we demonstrated a methodology of determination of transdermal rate of metallic microneedle array through impedance measurements-based numerical check screening algorithm. Metallic sheet microneedle array sensors with different sizes were fabricated to evaluate different transdermal rates. In vitro sensing of hydrogen peroxide confirmed the effect of transdermal rate on the sensing outcomes. An FEM simulation model of a microneedle array revealed the monotonous relation between the transdermal state and test current. Accordingly, two methods were primely derived to calculate the transdermal rate from the test current. First, an exact logic method provided the number of unpenetrated tips per sheet, but it required more rigorous testing results. Second, a fuzzy logic method provided an approximate transdermal rate on adjacent areas, being more applicable and robust to errors. Real-time transdermal rate estimation may be essential for improving the performance of microneedle systems, and this study provides various fundaments toward that goal.
微针系统已广泛应用于健康监测、无痛给药和医学美容领域。尽管已经开展了许多关于微针材料、结构和应用的研究，但由于皮肤-微针界面的复杂性，微针的应用常常存在渗透率不一致的问题。在本研究中，我们展示了一种基于阻抗测量的数值检查筛选算法来测定金属微针阵列经皮速率的方法。制造了不同尺寸的金属片微针阵列传感器来评估不同的经皮速率。体外过氧化氢传感证实了经皮速率对传感结果的影响。微针阵列的有限元模拟模型揭示了经皮状态与测试电流之间的单调关系。因此，主要推导出了两种从测试电流计算经皮速率的方法。第一种，精确逻辑方法提供了每张未穿透尖端的数量，但它需要更严格的测试结果。第二种，模糊逻辑方法提供了相邻区域的近似经皮速率，对误差更适用且更稳健。实时经皮速率估计对于提高微针系统的性能可能至关重要，本研究朝着该目标提供了各种基础。
