Scientific Department, Moscow State University of Food Production, 11 Volokolamskoe Hwy., 125080 Moscow, Russia.
Laboratory of Mechanochemistry, Institute of Solid State Chemistry and Mechanochemistry SB RAS, 18 Kutateladze, 630090 Novosibirsk, Russia.
Nutrients. 2022 May 10;14(10):1992. doi: 10.3390/nu14101992.
This study presents findings on the biological action of an integrated supplement containing the following components involved in osteogenesis and mineralization: vitamin D and silicon in the bioavailable and soluble form. A hypothesis that these components potentiate one another's action and make calcium absorption by the body more efficient was tested. Biological tests of the effect of vitamin D and silicon chelates on bone fracture healing and bone turnover were conducted using ICR mice and albino Wistar rats. Radiographic and biochemical studies show that the supplement simultaneously containing silicon chelates and vitamin D stimulates bone tissue regeneration upon mechanical defects and accelerates differentiation of osteogenic cells, regeneration of spongy and compact bones, and restoration of bone structure due to activation of osteoblast performance. Bone structure restoration was accompanied by less damage to skeletal bones, apparently due to better absorption of calcium from food. The studied supplement has a similar effect when used to manage physiologically induced decalcification, thus holding potential for the treatment of osteomalacia during pregnancy or occupational diseases (e.g., for managing bone decalcification in astronauts).
生物可利用和可溶性形式的维生素 D 和硅。测试了这些成分相互增强作用并使身体更有效地吸收钙的假设。使用 ICR 小鼠和白化 Wistar 大鼠进行了维生素 D 和硅螯合物对骨折愈合和骨转换影响的生物学测试。放射学和生化研究表明，同时含有硅螯合物和维生素 D 的补充剂可刺激机械缺陷处的骨组织再生，并加速成骨细胞的分化、海绵骨和密质骨的再生以及由于成骨细胞活性的增强而恢复骨结构。骨结构的恢复伴随着骨骼损伤的减少，显然是由于食物中钙的吸收更好。研究中的补充剂在管理生理性脱钙方面具有相似的效果，因此具有治疗妊娠或职业性疾病（例如，管理宇航员的骨脱钙）中佝偻病的潜力。
