Department of Bioenergetics and Physiology of Exercise, Medical University of Gdansk, 80-210 Gdansk, Poland.
Department of Pharmaceutical Biochemistry, Medical University of Gdansk, 80-211 Gdansk, Poland.
Nutrients. 2022 May 10;14(10):2000. doi: 10.3390/nu14102000.
The effect of metabolically active bariatric surgery treatment on lipid metabolism is inconclusive. The authors of this study presume that initial vitamin D status may play a regulating role in influencing the beneficial post-effects of bariatric surgery, especially the lipid profile. The biochemical data obtained from 24 patients who had undergone laparoscopic one-anastomosis gastric bypass (OAGB) at baseline, 3 months before the surgery, at the time of surgery, and 6 months later, demonstrate that vitamin D status influenced the postoperative lipid profile. The baseline established the partition line which divided patients into two groups according to the stated calcidiol initial concentration level of 32 ng/mL. The data shows that OAGB induces a decrease in TG and hsCRP while increasing HDL. Conversely, in patients whose 25(OH)D was below 32 ng/mL TC significantly increased while those above this concentration remained in the normal physiological range. The changes induced by OAGB in TG, glucose, and hsCRP were similar in both groups. Unexpectedly, the surgery did not affect vitamin D metabolites. In conclusion, the results of the study suggest that a higher concentration of serum 25(OH)D may enhance the protective effects of OAGB.
代谢活跃的减重手术治疗对脂代谢的影响尚无定论。本研究的作者推测，初始维生素 D 状态可能在影响减重手术的有益后期效应方面发挥调节作用，特别是在脂谱方面。从 24 名接受腹腔镜单吻合胃旁路术（OAGB）的患者在基线、手术前 3 个月、手术时和 6 个月获得的生化数据表明，维生素 D 状态影响术后脂谱。基线根据 32ng/ml 的初始 calcidiol 浓度水平将患者分为两组。数据显示，OAGB 诱导 TG 和 hsCRP 降低，而 HDL 增加。相反，在 25(OH)D 低于 32ng/ml 的患者中 TC 显著增加，而高于该浓度的患者则保持在正常生理范围内。两组患者的 OAGB 诱导的 TG、葡萄糖和 hsCRP 变化相似。出乎意料的是，手术并未影响维生素 D 代谢物。总之，研究结果表明，血清 25(OH)D 浓度较高可能增强 OAGB 的保护作用。
