Postgraduate Program in Nutrition, Federal University of Santa Catarina, Campus Universitário, Trindade, s/n, Florianópolis, 88.040-970, Brazil.
Postgraduate Program in Physical Education, Federal University of Triângulo Mineiro, Uberaba, Brazil.
Obes Surg. 2020 Sep;30(9):3301-3308. doi: 10.1007/s11695-020-04561-w.
Roux-en-Y gastric bypass (RYGB) is effective for weight loss but may have long-term effects on markers of oxidative stress (OS). The objective of this study is to evaluate the effect of bariatric surgery with RYGB on OS blood markers in a 72-month period after surgery.
A prospective cohort study was conducted with 20 patients before and after RYGB (months M0, M6, M12, M24, and M72) compared with a control group of 35 adults assessed only once.
The body mass index (BMI) (45.71 ± 6.97 kg/m) decreased by 38% from M0 to M24 (17.51 ± 5.50 kg/m, p < 0.001), followed by a 12% increase from M24 to M72 (p < 0.001). Serum concentrations of vitamin E (adjusted for total cholesterol and triglycerides) and vitamin C increased throughout the study (p < 0.001). β-carotene levels decreased progressively through to M72 (p = 0.008). Reduced glutathione (GSH) content and catalase (CAT) activity decreased at M6, M12, and M24, but no differences were found at M72 compared with M0. Concentrations of thiobarbituric acid reactive substances (TBARS) were lower M12 and M24 in comparison with baseline values (p < 0.001 and p = 0.004, respectively) but were similar to baseline values at 72 months (p = 0.114).
GSH content, TBARS concentrations, and CAT activity returned to baseline values 72 months after RYGB, indicating the persistence of systemic OS, possibly attributable to weight regain and/or changes in the antioxidant defenses, such as the reduction in β-carotene levels.
Roux-en-Y 胃旁路手术（RYGB）在减肥方面效果显著，但可能对氧化应激（OS）标志物产生长期影响。本研究旨在评估 RYGB 减肥手术后 72 个月内对 OS 血液标志物的影响。
对 20 例 RYGB 前后患者（M0、M6、M12、M24 和 M72 个月）进行前瞻性队列研究，并与仅评估一次的 35 例成人对照组进行比较。
体重指数（BMI）（45.71±6.97kg/m²）从 M0 到 M24 降低了 38%（17.51±5.50kg/m²，p<0.001），随后从 M24 到 M72 增加了 12%（p<0.001）。血清维生素 E（经总胆固醇和甘油三酯调整）和维生素 C 浓度在整个研究过程中均升高（p<0.001）。β-胡萝卜素水平逐渐下降至 M72（p=0.008）。还原型谷胱甘肽（GSH）含量和过氧化氢酶（CAT）活性在 M6、M12 和 M24 时降低，但在 M72 时与 M0 相比无差异。与基线值相比，M12 和 M24 时的硫代巴比妥酸反应物质（TBARS）浓度较低（p<0.001 和 p=0.004），但在 72 个月时与基线值相似（p=0.114）。
RYGB 后 72 个月，GSH 含量、TBARS 浓度和 CAT 活性恢复到基线值，表明全身 OS 持续存在，可能归因于体重反弹和/或抗氧化防御的变化，如β-胡萝卜素水平降低。
