Department of Obstetrics and Gynecology, Division of Maternal and Fetal Medicine, La Paz University Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain.
Department of Clinical Chemistry, La Paz University Hospital, 28046 Madrid, Spain.
Nutrients. 2022 May 23;14(10):2172. doi: 10.3390/nu14102172.
Antiangiogenic factors are currently used for the prediction of preeclampsia. The present study aimed to evaluate the relationship between antiangiogenic factors and lipid and carbohydrate metabolism in maternal plasma and placenta. We analyzed 56 pregnant women, 30 healthy and 26 with preeclampsia (including early and late onset). We compared antiangiogenic factors soluble Fms-like Tyrosine Kinase-1 (sfLt-1), placental growth factor (PlGF), and soluble endoglin (sEng)), lipid and carbohydrate metabolism in maternal plasma, and lipid metabolism in the placenta from assays of fatty acid oxidation, fatty acid esterification, and triglyceride levels in all groups. Antiangiogenic factors sFlt-1, sFlt-1/PlGF ratio, and sEng showed a positive correlation with triglyceride, free fatty acid, and C-peptide maternal serum levels. However, there was no relationship between angiogenic factors and placental lipid metabolism parameters. Free fatty acids were predictive of elevated sFlt-1 and sEng, while C-peptide was predictive of an elevated sFlt1/PlGF ratio. The findings in this study generate a model to predict elevated antiangiogenic factor values and the relationship between them with different products of lipid and carbohydrate metabolism in maternal serum and placenta in preeclampsia.
抗血管生成因子目前用于预测子痫前期。本研究旨在评估母体血浆和胎盘抗血管生成因子与脂质和碳水化合物代谢之间的关系。我们分析了 56 名孕妇，30 名健康孕妇和 26 名子痫前期孕妇（包括早发型和晚发型）。我们比较了抗血管生成因子可溶性 fms 样酪氨酸激酶-1（sfLt-1）、胎盘生长因子（PlGF）和可溶性内皮素（sEng））、母体血浆中的脂质和碳水化合物代谢，以及所有组中脂肪酸氧化、脂肪酸酯化和甘油三酯水平的胎盘脂质代谢。抗血管生成因子 sFlt-1、sFlt-1/PlGF 比值和 sEng 与甘油三酯、游离脂肪酸和 C 肽呈正相关。然而，血管生成因子与胎盘脂质代谢参数之间没有关系。游离脂肪酸可预测 sFlt-1 和 sEng 升高，而 C 肽可预测 sFlt1/PlGF 比值升高。本研究的结果提出了一种模型，用于预测子痫前期母体血清和胎盘不同脂质和碳水化合物代谢产物中升高的抗血管生成因子值及其之间的关系。
