Souan Lina, Sughayer Maher A, Abualhour Maha M, Siag Mahmoud, Al-Badr Sara, Al-Atrash Tareq
Department of Pathology & Laboratory Medicine, King Hussein Cancer Center, Amman 11941, Jordan.
Vaccines (Basel). 2022 Apr 20;10(5):642. doi: 10.3390/vaccines10050642.
Background: The effective immunization of healthcare workers (HCWs) plays a vital role in preventing the spread of SARS-CoV-2 infection during the coronavirus disease 2019 (COVID-19) pandemic. There is limited data on the immune response to vaccination among HCWs. We aim to determine seroprevalence rates and neutralizing IgG antibody response to various immunizations among HCWs. Methods: This study was conducted between July and September 2021, in which blood samples were obtained from HCWs and SARS-CoV-2 IgG neutralizing antibodies were measured. Data regarding vaccination status with Pfizer/BioNTech, Sinopharm, or AstraZeneca vaccines, occupation, and prior COVID-19 infection were analyzed. Results: COVID-19 infection post-vaccination was associated with higher mean antibody titers, regardless of vaccine type. Pfizer/BioNTech vaccination produced higher mean antibody titers for HCWs with prior COVID-19 infection (p < 0.00001) than other types of vaccines. Although 96% of HCWs were vaccinated, 3% were seronegative. For HCWs who were seropositive, there were no significant differences between the mean antibody titers when comparing occupations and blood indices. Conclusion: Awareness of the immunity status of HCWs is key to protecting this important group against SARS-CoV-2, especially those without prior COVID-19 infection. Further public health efforts regarding booster vaccination for HCWs are crucial to provide necessary antibody protection.
在2019冠状病毒病（COVID-19）大流行期间，医护人员（HCWs）的有效免疫接种在预防严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）感染传播方面发挥着至关重要的作用。关于医护人员对疫苗接种的免疫反应的数据有限。我们旨在确定医护人员中各种免疫接种后的血清阳性率和中和IgG抗体反应。方法：本研究于2021年7月至9月进行，采集医护人员的血样并检测SARS-CoV-2 IgG中和抗体。分析了关于辉瑞/生物新技术公司、国药集团或阿斯利康疫苗的接种状况、职业和既往COVID-19感染的数据。结果：无论疫苗类型如何，接种疫苗后感染COVID-19均与较高的平均抗体滴度相关。对于既往感染过COVID-19的医护人员，辉瑞/生物新技术公司疫苗接种产生的平均抗体滴度（p < 0.00001）高于其他类型的疫苗。尽管96%的医护人员接种了疫苗，但3%的人血清学检测呈阴性。对于血清学检测呈阳性的医护人员，比较职业和血液指标时，平均抗体滴度之间没有显著差异。结论：了解医护人员的免疫状态是保护这一重要群体免受SARS-CoV-2感染的关键，尤其是那些既往未感染过COVID-19的人员。针对医护人员加强接种的进一步公共卫生努力对于提供必要的抗体保护至关重要。
