Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Viruses. 2022 May 18;14(5):1084. doi: 10.3390/v14051084.
The duel between humans and viruses is unending. In this review, we examine the HIV RNA in the form of un-translated terminal region (UTR), the viral DNA in the form of long terminal repeat (LTR), and the immunity of human DNA in a format of epigenetic regulation. We explore the ways in which the human immune responses to invading pathogenic viral nucleic acids can inhibit HIV infection, exemplified by a chromatin vaccine (cVaccine) to elicit the immunity of our genome-epigenetic immunity towards a cure.
人类与病毒的斗争永无止境。在这篇综述中，我们研究了 HIV RNA 以未翻译的末端区域（UTR）的形式、病毒 DNA 以长末端重复（LTR）的形式以及人类 DNA 的免疫以表观遗传调控的形式。我们探讨了人类对入侵的致病病毒核酸的免疫反应如何抑制 HIV 感染的方式，例如通过染色质疫苗（cVaccine）引发我们基因组-表观遗传免疫对治愈的免疫。
