Fouquet B, Renoux M, Eveleich M C, Bardos P, Valat J P
Rev Rhum Mal Osteoartic. 1987 Jan;54(1):31-5.
The immuno-enzymatic method permits the separate study of rheumatoid factors (RF): IgM as well as IgG, IgA, IgE, IgD. In 43 patients with rheumatoid polyarthritis (RP), classic or definite, we have studied the correlations between the various parameters of articular and extraarticular activity of RP and the levels of each isotype of RF. A statistically significant correlation of the articular activity was found with RF IgG (p less than 0.01), RF IgA (p less than 0.01). As compared to RP without rheumatoid nodule, RPs with rheumatoid nodules presented a level of RF IgM (p less than 0.05), RF IgG, IgA, IgE (p less than 0.01) which was statistically higher; a statistically significant correlation was found between haptoglobin levels and those of RF IgG (p less than 0.01). A negative correlation, statistically significant, was found between CH 50 and the levels of RF IgM. This study confirms previous studies which were carried out with an immuno-enzymatic method of detection of RF isotypes.
免疫酶法可对类风湿因子（RF）进行单独研究：包括IgM以及IgG、IgA、IgE、IgD。在43例典型或确诊的类风湿性多关节炎（RP）患者中，我们研究了RP关节和关节外活动的各种参数与每种RF同种型水平之间的相关性。发现关节活动与RF IgG（p<0.01）、RF IgA（p<0.01）存在统计学显著相关性。与无类风湿结节的RP相比，有类风湿结节的RP患者的RF IgM水平（p<0.05）、RF IgG、IgA、IgE水平（p<0.01）在统计学上更高；发现触珠蛋白水平与RF IgG水平之间存在统计学显著相关性（p<0.01）。发现CH 50与RF IgM水平之间存在统计学显著的负相关性。本研究证实了先前采用免疫酶法检测RF同种型所进行的研究。
