Bardin T, Enel C, Lathrop M G
Rev Rhum Mal Osteoartic. 1987 Jan;54(1):37-43.
A clinical and epidemiological study of the Fiessinger Leroy Reiter syndrome was undertaken in Inuits from four Greenland cities, because of the frequency of HLA B27 antigen and venereal diseases in this population. A mean prevalence of 0.67 p. cent was found in Inuits from the west coast, of which 27.5 p. cent are carriers of the HLA B27 antigen. In Amassalik, on Greenland's east coast, where the frequency of B27 was estimated at 6.5 p. cent, the prevalence of the syndrome is 0.32 p. cent. Immunogenetic and preliminary familial data show that HLA B27 is present in 87.5 p. cent of the patients and that 34 p. cent have a close relative with the disease. Clinical data are comparable to those reported in the literature. Evolution is marred by frequent recurrences: 85 p. cent of the patients followed for more than ten (10) years present at least one recurrence. The total frequency of ankylosing spondylarthritis is 16.7 p. cent. It increases, in retrospect, to reach 45 p. cent in 22 patients followed for more than 15 years.
由于该人群中HLA B27抗原和性病的高发性，对来自格陵兰四个城市的因纽特人进行了费辛格-勒鲁瓦-赖特综合征的临床和流行病学研究。在西海岸的因纽特人中发现平均患病率为0.67%，其中27.5%为HLA B27抗原携带者。在格陵兰东海岸的阿马萨利克，B27的频率估计为6.5%，该综合征的患病率为0.32%。免疫遗传学和初步家族数据显示，87.5%的患者存在HLA B27，34%的患者有患该病的近亲。临床数据与文献报道的数据相当。病情发展常因频繁复发而受阻：在随访超过10年的患者中，85%至少复发过一次。强直性脊柱炎的总发病率为16.7%。回顾过去，在随访超过15年的22名患者中，发病率增至45%。
