Bai Wei, Feng Yuan, Sha Sha, Zhang Qinge, Cheung Teris, Zhang Dexing, Su Zhaohui, Ng Chee H, Xiang Yu-Tao
Unit of Psychiatry, Department of Public Health and Medicinal Administration, Faculty of Health Sciences, Institute of Translational Medicine, University of Macau, Macao, Macao SAR, China.
Center for Cognition and Brain Sciences, University of Macau, Macao, Macao SAR, China.
Front Psychiatry. 2022 May 12;13:881414. doi: 10.3389/fpsyt.2022.881414. eCollection 2022.
Hypomanic symptoms between bipolar-I disorder (BD-I) and bipolar-II disorder (BD-II) are often indistinguishable in clinical practice. This study compared the network structure of hypomanic symptoms between patients with BD-I and BD-II.
The 32-item Hypomania Checklist (HCL-32) was used to assess hypomanic symptoms. Network model was generated in BD-I and BD-II patients. Centrality index of strength was used to quantify the importance of each symptom in the network. The Network Comparison Test (NCT) was used to assess the differences in hypomanic symptoms between BD-I and BD-II patients.
Altogether, 423 patients with BD (BD-I: 191 and BD-II: 232) were included. The most central symptom was HCL17 "I am more flirtatious and/or am more sexually active" (strength = 5.21) and HCL12 "I have more ideas, I am more creative" (strength = 6.84) in BD-I and BD-II samples, respectively. The results of NCT showed that four nodes (HCL12 "I have more ideas, I am more creative," HCL17 "I am more flirtatious and/or am more sexually active," HCL23 "My thoughts jump from topic to topic," and HCL31 "I drink more alcohol") were significantly different between the BD-I and BD-II samples. Two edges (HCL3 "I am more self-confident"-HCL17 "I am more flirtatious and/or am more sexually active," and HCL10 "I am physically more active (sport, etc.)"-HCL24 "I do things more quickly and/or more easily") were significantly stronger in BD-I compared to BD-II patients.
The network structure of hypomanic symptoms is different between BD-I and BD-II patients. Interventions targeting the respective central symptoms and edges should be developed for BD-I and BD-II separately.
在临床实践中，双相I型障碍（BD-I）和双相II型障碍（BD-II）的轻躁狂症状往往难以区分。本研究比较了BD-I和BD-II患者轻躁狂症状的网络结构。
采用32项轻躁狂症状清单（HCL-32）评估轻躁狂症状。在BD-I和BD-II患者中生成网络模型。使用强度中心性指数来量化每种症状在网络中的重要性。采用网络比较检验（NCT）评估BD-I和BD-II患者轻躁狂症状的差异。
共纳入423例双相障碍患者（BD-I：191例，BD-II：232例）。在BD-I和BD-II样本中，最核心的症状分别是HCL17“我更爱调情和/或性活动更频繁”（强度=5.21）和HCL12“我的想法更多，更有创造力”（强度=6.84）。NCT结果显示，BD-I和BD-II样本之间有四个节点（HCL12“我的想法更多，更有创造力”、HCL17“我更爱调情和/或性活动更频繁”、HCL23“我的思维从一个话题跳到另一个话题”和HCL31“我饮酒更多”）存在显著差异。与BD-II患者相比，两条边（HCL3“我更自信”-HCL17“我更爱调情和/或性活动更频繁”，以及HCL10“我身体更活跃（运动等）”-HCL24“我做事更快和/或更容易”）在BD-I患者中显著更强。
BD-I和BD-II患者轻躁狂症状的网络结构不同。应分别针对BD-I和BD-II制定针对各自核心症状和边的干预措施。
