Department of Physiology and Pathophysiology, School of Basic Medical Sciences, and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Peking University, Beijing, China.
Department of Surgery, University of Michigan Medical Center, Ann Arbor, MI, United States.
Front Endocrinol (Lausanne). 2022 Apr 27;13:855197. doi: 10.3389/fendo.2022.855197. eCollection 2022.
Obesity, a growing chronic metabolic disease, greatly increases the risk of metabolic syndrome which includes type 2 diabetes, fatty liver and cardiovascular diseases. Obesity-associated metabolic diseases significantly contribute to mortality and reduce life expectancy. Recently, innate lymphoid cells (ILCs) have emerged as crucial regulators of metabolic homeostasis and tissue inflammation. This review focuses on the roles of ILCs in different metabolic tissues, including adipose tissue, liver, pancreas, and intestine. We briefly outline the relationship between obesity, inflammation, and insulin resistance. We then discuss how ILCs in distinct metabolic organs may function to maintain metabolic homeostasis and contribute to obesity and its associated metabolic diseases. The potential of ILCs as the therapeutic target for obesity and insulin resistance is also addressed.
肥胖是一种日益严重的慢性代谢性疾病，极大地增加了代谢综合征的风险，其中包括 2 型糖尿病、脂肪肝和心血管疾病。与肥胖相关的代谢性疾病显著增加了死亡率并降低了预期寿命。最近，天然淋巴细胞 (ILC) 已成为代谢稳态和组织炎症的重要调节因子。本综述重点介绍了 ILC 在不同代谢组织（包括脂肪组织、肝脏、胰腺和肠道）中的作用。我们简要概述了肥胖、炎症和胰岛素抵抗之间的关系。然后，我们讨论了不同代谢器官中的 ILC 如何发挥作用以维持代谢稳态，并导致肥胖及其相关代谢性疾病。我们还探讨了将 ILC 作为肥胖和胰岛素抵抗治疗靶点的潜力。
