The Ophthalmology Department of the Affiliated Chenzhou Hospital, Hengyan Medical School, University of South China, Chenzhou, Hunan, China 423000.
Department of Pathogenic Biology and Immunology, Xiangnan University, Chenzhou, Hunan, China 423000.
Dis Markers. 2022 May 20;2022:5338725. doi: 10.1155/2022/5338725. eCollection 2022.
To observe the morphological changes of corneal endothelial cells in healthy Chinese children and youngsters and analyze the sensitive and specificity of the endothelial assessments.
14,670 Chinese healthy volunteers enrolled were examined by specular microscopy, and the endothelial descriptive indexes: the central corneal thickness (CCT), endothelial cell density (ECD), coefficient of variation in average cell size (CV), the percentage of regular hexagonal cells (hexagonality, HEX), cell size of minimal cell ( ), cell size of maximal cell ( ), average cell size ( ), and size of standard deviation of cell area ( ) as well as sex and age were analyzed.
The average age of this study is 17.36 ± 7.58 (4-30) years. There is no sex predominance: 7,260 male (49.5%) and 7,410 female (50.5%). The mean CCT, ECD, CV, HEX, , , and are 529.94 ± 31.53 (437-644) m, 3,051.28 ± 375.49 (2,031-4,074) cells/mm, 28.34 ± 4.36 (18-40) %, 61.21 ± 10.29 (17-89) %, (147.79 ± 21.94 to 678.29 ± 120.96) m, 332.74 ± 44.62 m, and 95.02 ± 23.17 m, respectively. The CCTs keep consistency. The ECD decreased rate is 1.02%/year. The curve of ECD and hexagonality expresses the same linear tender. The CCT and endothelial evaluation indexes have no sex predominant ( > 0.05); the quantitative indicators: CCT, ECD, and HEX are significant negative associated with age ( = 0.001 or < 0.001); the variability indexes: the CV, , , , and are positive correlation ( < 0.001). The coefficients of CCT, HE, and are -0.35, -0.59, and 1.17, respectively.
The ECD decrease rate is 1.02%/year of the normal Chinese Han childhood to the earlier adulthood. The ages 4 to 12, 13 to 20, and 21 to 30 can be named as the childhood, puberty and adulthood from endothelial biologic identity. The HEX is the sensitivity marks for the polymorphisms while the S is the specificity indicator CVs upon the Topcon Noncon Specular microscopy results.
观察健康中国儿童和青少年的角膜内皮细胞形态变化，并分析内皮评估的敏感性和特异性。
对 14670 名中国健康志愿者进行共焦显微镜检查，分析内皮描述性指标：中央角膜厚度（CCT）、内皮细胞密度（ECD）、平均细胞大小变异系数（CV）、规则六边形细胞百分比（HEX）、最小细胞面积（ ）、最大细胞面积（ ）、平均细胞面积（ ）、细胞面积标准差（ ）以及性别和年龄。
本研究平均年龄为 17.36 ± 7.58 岁（4-30 岁）。无性别优势：男性 7260 名（49.5%），女性 7410 名（50.5%）。平均 CCT、ECD、CV、HEX、 、 、 分别为 529.94 ± 31.53 µm（437-644）、3051.28 ± 375.49 个/mm²（2031-4074）、28.34 ± 4.36%（18-40）、61.21 ± 10.29%（17-89）、（147.79 ± 21.94 至 678.29 ± 120.96）µm、332.74 ± 44.62 µm 和 95.02 ± 23.17 µm。CCT 保持一致。ECD 的年下降率为 1.02%。ECD 和 HEX 的曲线表达相同的线性趋势。CCT 和内皮评估指标无性别优势（ > 0.05）；定量指标：CCT、ECD 和 HEX 与年龄呈显著负相关（ = 0.001 或 < 0.001）；变异性指标：CV、 、 、 、 呈正相关（ < 0.001）。CCT、HE 和 的系数分别为-0.35、-0.59 和 1.17。
正常中国汉族儿童至成年早期 ECD 下降率为 1.02%/年。年龄 4-12 岁、13-20 岁和 21-30 岁可分别称为儿童期、青春期和成年期，从内皮生物学特征来看。HEX 是多态性的敏感标志，而 S 是 Topcon Noncon Specular 显微镜结果的 CVs 的特异性指标。
