Pécoud A
Schweiz Med Wochenschr. 1987 Feb 14;117(7):252-5.
To investigate the possible role of allergy in asthma or chronic rhinitis, four groups of tests can be used. The patient's history, which is the best way to determine the severity of the disease and the clinical relevance of the allergens detected by other diagnostic means. Tests which disclose an atopic constitution. The predictive value of the serum level of total IgE is somewhat lessened by 20-30% false positive and false negative results. Phadiatop, introduced in 1986, appears to be a more accurate screening test for respiratory allergy. Tests which disclose the presence of allergen-specific IgE, in the skin (skin tests) or in serum (RAST). Tests which reproduce the allergic disease in the shock organ (conjunctival, nasal and bronchial provocation tests). These tests are used in clinical research rather than in the routine diagnosis of allergy.
为研究过敏在哮喘或慢性鼻炎中可能发挥的作用,可采用四类检测方法。患者病史是确定疾病严重程度以及其他诊断方法所检测出的过敏原临床相关性的最佳途径。能揭示特应性体质的检测。血清总IgE水平的预测价值因20% - 30%的假阳性和假阴性结果而有所降低。1986年推出的Phadiatop似乎是一种更准确的呼吸道过敏筛查检测。能揭示皮肤(皮肤试验)或血清(放射性变应原吸附试验)中过敏原特异性IgE存在的检测。能在休克器官再现过敏性疾病的检测(结膜、鼻和支气管激发试验)。这些检测用于临床研究而非过敏的常规诊断。