Department of Pediatric Cardiology, Rajaiee Heart Center, Tehran, Iran.
Liver and Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Iran J Med Sci. 2022 May;47(3):256-263. doi: 10.30476/IJMS.2021.88464.1919.
There is no compelling evidence to prove an association between serum free L-carnitine levels and changes in left ventricular (LV) geometry. The present study aimed to evaluate a possible association between these parameters.
In a cross-sectional study, 504 outpatients were randomly selected among those registered at Sanandaj Pediatric Heart Clinic (Sanandaj, Iran) during 2014-2020. The patients aged one to 25 years and were presented with cardiac complaints. The serum L-carnitine levels of all patients were evaluated and associated with changes in LV geometry measured by echocardiography. The association was assessed using the Chi squared test, Fisher's exact test, and one-way ANOVA with Tukey test. Data were analyzed using SPSS software (version 22.0). P≤0.05 was considered statistically significant.
The mean serum L-carnitine levels in the normal, low, and high serum groups were 52.69, 14.16, and 178.67 nmol/dL, respectively. There was a significant statistical association between abnormal serum levels of free L-carnitine and changes in LV geometry (P<0.001).
Our findings are indicative of an association between abnormal serum L-carnitine levels and changes in LV geometry in pediatric and adolescent patients.
目前尚无确凿证据证明血清游离左旋肉碱水平的变化与左心室（LV）几何形状的变化之间存在关联。本研究旨在评估这两个参数之间可能存在的关联。
本研究采用横断面研究方法，于 2014 年至 2020 年期间，在伊朗 Sanandaj 儿科心脏诊所随机选择了 504 名年龄在 1 至 25 岁之间、有心脏不适症状的门诊患者。评估了所有患者的血清左旋肉碱水平，并通过超声心动图测量 LV 几何形状的变化。采用卡方检验、Fisher 确切检验和单向方差分析（Tukey 检验）评估相关性。采用 SPSS 软件（版本 22.0）对数据进行分析。P≤0.05 为差异有统计学意义。
血清正常、低和高游离肉碱组的平均血清左旋肉碱水平分别为 52.69、14.16 和 178.67 nmol/dL。游离左旋肉碱血清水平异常与 LV 几何形状的变化之间存在显著的统计学关联（P<0.001）。
我们的研究结果表明，血清左旋肉碱水平异常与儿科和青少年患者 LV 几何形状的变化之间存在关联。
