Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen 518060, China.
Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.
Anal Chem. 2022 Jun 14;94(23):8399-8408. doi: 10.1021/acs.analchem.2c00929. Epub 2022 May 28.
Retaining intrinsic photophysical performance and efficient therapeutic efficacy of cyanine dyes in the second near-infrared (NIR-II) biowindow are challenges in the biomedical field. Herein, we develop a metal ion-assisted NIR-II fluorophore assembly strategy to modulate molecular arrangement behavior, thus overcoming the drawbacks and retaining the photophysical performance of cyanine dyes in aqueous media for cancer phototheranostics. By screening a series of metal ion-assisted fluorophore assemblies, we remarkably found gadolinium-based metallo-dye-supramolecular nanoassembly (denoted as Gd@IR1064) with the intrinsic optical properties of NIR-II cyanine dye (IR1064). Most intriguingly, the as-prepared Gd@IR1064 not only exhibits deep-tissue-penetrating NIR-II photoacoustic, fluorescence, and magnetic resonance imaging ability but also possesses enhanced photothermal conversion performance-induced hyperthermia, achieving a significant tumor elimination effect. Our study provides a promising guide for modulating dye arrangement with unique photophysical performance for biomedical applications.
在生物医学领域，如何保持近红外二区（NIR-II）生色团的固有光物理性能并提高其治疗效果是一个挑战。在此，我们开发了一种金属离子辅助的 NIR-II 荧光团组装策略，以调控分子排列行为，从而克服缺点并保留生色团在水相中的光物理性能，用于癌症光热治疗。通过筛选一系列金属离子辅助的荧光团组装体，我们显著发现基于钆的金属染料超分子纳米组装体（表示为 Gd@IR1064）具有 NIR-II 生色团（IR1064）的固有光学性质。最有趣的是，所制备的 Gd@IR1064 不仅表现出深组织穿透的 NIR-II 光声、荧光和磁共振成像能力，而且还具有增强的光热转换性能诱导的热疗，实现了显著的肿瘤消除效果。我们的研究为调节具有独特光物理性能的染料排列以用于生物医学应用提供了有前景的指导。
