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SL 25对颈部和面部肿瘤放疗中放射性口干的影响(作者译)

[Effect of SL 25 on radiogenic xerostomia in the radiotherapy of tumors in the region of neck and face (author's transl)].

作者信息

Hassenstein E, Müller R, Reinhard H J

出版信息

Strahlentherapie. 1978 Aug;154(8):554-8.

PMID:356350
Abstract

The radiogenic xerostomia often poses problems to the radiotherapeutist because this symptom can become so severe that treatment has to be interrupted or in some cases even stopped. The therapeutic success can become uncertain because of such deviations from the irradiation scheme. Because of promising observations reported in literature, we have examined the stimulating effect on the salivation produced by the test preparation SL 25 from Kali-Chemie Pharma GmbH in Hannover. A double blindfold test was made. Only three out of fourteen patients (22%) in the active substance group declared to feel a relief of the xerostomia, whereas in the control group five out of twenty patients (25%) felt this relief.

摘要

放射性口干常常给放疗医师带来难题,因为这种症状可能会变得非常严重,以至于不得不中断治疗,在某些情况下甚至要停止治疗。由于与照射方案出现这样的偏差,治疗效果可能变得不确定。鉴于文献中报道的有前景的观察结果,我们研究了汉诺威的卡利化学制药有限公司生产的试验制剂SL 25对唾液分泌的刺激作用。进行了双盲试验。活性物质组的14名患者中只有3名(22%)称口干症状有所缓解,而对照组的20名患者中有5名(25%)有此感觉。

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