Celik Serdal, Kilic Osman, Zenginkinet Tulay, Tuysuz Ozan, Kalcioglu M Tayyar
485544Istanbul Medeniyet University Faculty of Medicine, Department of Otorhinolaryngology, Istanbul, Turkey.
Istanbul Medeniyet University Faculty of Medicine, Department of Pathology, Istanbul, Turkey.
Am J Rhinol Allergy. 2022 Nov;36(6):719-726. doi: 10.1177/19458924221104547. Epub 2022 May 29.
Conservative approaches and surgical methods have been tried for the treatment of nasal septum perforations (NSPs), but a satisfactory method has not yet been determined.
Our study aimed to investigate the effect of platelet-rich fibrin (PRF) and hyaluronic acid (HA) in repairing NSPs, which were experimentally created in rabbit septum.
A total of 36 white New Zealand rabbits were included in the study. Perforations measuring 0.7 × 0.7 cm were created in their nasal septa. No additional intervention was made to the control group, which was the first group. For the second, third, and fourth groups, respectively, HA, PRF, and HA + PRF were used in the NSP region. Macroscopic and histopathological evaluations were performed after 40 days.
In the first group, closure was observed in none of the rabbits' NSPs. In the second group, 6 rabbits (66.7%) had full closure in their NSPs. In the third group, the NSP of 6 rabbits (66.7%) was completely closed. In the fourth group, the NSP of 7 rabbits (77.8%) had full closure.
Statistically significant closure was achieved with PRF and/or HA in rabbits in which NSP was established. These materials can be used to increase the likelihood of perforations closing.
已尝试采用保守方法和手术方法治疗鼻中隔穿孔（NSP），但尚未确定一种令人满意的方法。
本研究旨在探讨富血小板纤维蛋白（PRF）和透明质酸（HA）对兔鼻中隔实验性制造的NSP修复的效果。
本研究共纳入36只白色新西兰兔。在其鼻中隔制造0.7×0.7厘米的穿孔。第一组为对照组，未进行额外干预。第二、三、四组分别在NSP区域使用HA、PRF和HA + PRF。40天后进行宏观和组织病理学评估。
第一组中，没有一只兔子的NSP闭合。第二组中，6只兔子（66.7%）的NSP完全闭合。第三组中，6只兔子（66.7%）的NSP完全闭合。第四组中，7只兔子（77.8%）的NSP完全闭合。
在制造了NSP的兔子中，PRF和/或HA实现了具有统计学意义的闭合。这些材料可用于增加穿孔闭合的可能性。
