Faculdade de Medicina da Santa Casa de São Paulo.
Braz J Otorhinolaryngol. 2010 Jul-Aug;76(4):442-9. doi: 10.1590/S1808-86942010000400007.
Alloplastic materials can be used together with tissue and structure to close nasal septal perforation.
to test cellulose use in the closure of septal perforation in rabbits and to compare fibrosis, inflammation, vascular congestion and graft integrity.
Fifteen rabbits. The rabbits were divided into two groups:
Five rabbits and Bionext and fibrin glue Tissucol: Ten rabbits. Septal perforations were done in all of them. In the Bionext group the closure was performed with the placement of cellulose.
Two rabbits died in the first week. Cellulose group: 2 closures without the cellulose in between the septum membrane and in 4 cases the graft stood in the middle of the perforation locked in place by the edges. No closure in the control group.
There was no closure of the perforation of the nasal septum with the graft between the septum membranes. There was no statistically significant difference concerning acute inflammation, vascular congestion and fibrosis between the 2 groups. In cases in which the graft remained in place, there was no change in its integrity. It may be used as a substructure for re-epithelization of the perforation edges.
可以使用同种异体材料与组织和结构一起封闭鼻中隔穿孔。
在兔子中测试纤维素用于封闭鼻中隔穿孔，并比较纤维化、炎症、血管充血和移植物完整性。
15 只兔子。兔子被分为两组：
5 只兔子和 Bionext 和纤维蛋白胶 Tissucol：10 只兔子。所有兔子都进行了鼻中隔穿孔。在 Bionext 组中，使用纤维素进行封闭。
第一周有 2 只兔子死亡。纤维素组：2 例无纤维素在鼻中隔膜之间，4 例移植物位于穿孔中间，被边缘锁定在适当位置。对照组无封闭。
用移植物在鼻中隔膜之间没有封闭鼻中隔穿孔。两组之间的急性炎症、血管充血和纤维化无统计学差异。在移植物保持原位的情况下，其完整性没有变化。它可作为穿孔边缘再上皮化的亚结构使用。
