Department of Chemical and Environmental Engineering, 'Materials+Technologies' Group. Engineering College of Gipuzkoa, University of the Basque Country (UPV/EHU), Plaza Europa 1, 20018, Donostia-San Sebastián, Spain.
Int J Pharm. 2022 Jun 25;622:121872. doi: 10.1016/j.ijpharm.2022.121872. Epub 2022 May 27.
Starch-based tablets with tailored releases were prepared by 3D printing using a hydrophobic drug. The importance of the origin of the excipient in the inks and tablets was analyzed. Besides, the effect of the geometry of the tablet on the drug release profile was also evaluated. The rheological properties of the inks was influenced by the botanic origin of the starch. Consequently, tablets presented different microporous structure and particular compression and swelling behaviors. Normal maize starch showed a non-well-defined porous morphology, not being able to form a stable structure whereas, waxy maize and potato starches exhibited a well-defined porous structure and were both able to maintain their integrity after long time immersion. Finally, tablets combining different starches and geometries were printed tailoring the drug release from 10 min to 6 h and designing two-steps profiles. The applicability of the developed 3D printed drug release systems in personalized therapies was demonstrated.
通过 3D 打印技术，使用疏水性药物制备了具有定制释放特性的淀粉基片剂。分析了墨水和片剂中赋形剂来源的重要性。此外，还评估了片剂的几何形状对药物释放曲线的影响。墨水的流变性能受淀粉的植物来源影响。因此，片剂呈现出不同的微孔结构和特殊的压缩和溶胀行为。普通玉米淀粉呈现出非明确的多孔形态，无法形成稳定的结构，而蜡质玉米淀粉和马铃薯淀粉则表现出明确的多孔结构，并且在长时间浸泡后仍能保持完整性。最后，通过打印组合不同淀粉和几何形状的片剂，实现了药物释放时间从 10 分钟到 6 小时的定制，并设计了两步释放曲线。证明了所开发的 3D 打印药物释放系统在个性化治疗中的适用性。
