Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Infect Dis Clin North Am. 2022 Jun;36(2):251-265. doi: 10.1016/j.idc.2022.01.004. Epub 2022 Jan 31.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first identified in 2020 and has led to an unprecedented global pandemic. Understanding the virology behind SARS-CoV-2 infection has provided key insights into our efforts to develop antiviral agents and control the COVID-19 pandemic. In this review, the authors focus on the genomic features of SARS-CoV-2, its intrahost and interhost evolution, viral dynamics in respiratory tract, and systemic dissemination.
严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）于 2020 年首次被发现，并导致了一场前所未有的全球大流行。了解 SARS-CoV-2 感染背后的病毒学为我们开发抗病毒药物和控制 COVID-19 大流行的努力提供了关键的见解。在这篇综述中，作者重点关注 SARS-CoV-2 的基因组特征、其在宿主内和宿主间的进化、呼吸道中的病毒动力学以及系统传播。
