多种病原体与前列腺癌
Multiple pathogens and prostate cancer.
作者信息
Lawson James S, Glenn Wendy K
机构信息
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, 2052, Australia.
出版信息
Infect Agent Cancer. 2022 May 30;17(1):23. doi: 10.1186/s13027-022-00427-1.
BACKGROUND
The aim of this review is to consider whether multiple pathogens have roles in prostate cancer.
METHODS
We have reviewed case control studies in which infectious pathogens in prostate cancer were compared to normal and benign prostate tissues. We also reviewed additional evidence from relevant published articles.
RESULTS
We confirmed that high risk human papilloma viruses are a probable cause of prostate cancer. We judged Escherichia coli, Cutibacterium acnes, Neisseria gonorrhoea, Herpes simplex, Epstein Barr virus and Mycoplasmas as each having possible but unproven roles in chronic prostatic inflammation and prostate cancer. We judged Cytomegalovirus, Chlamydia trachomatis, Trichomonas vaginalis and the Polyoma viruses as possible but unlikely to have a role in prostate cancer.
CONCLUSIONS AND ACTIONS
The most influential cause of prostate cancer appears to be infection induced chronic inflammation. Given the high prevalence of prostate cancer it is important for action to can be taken without waiting for additional conclusive evidence. These include: 1. Encouragement of all boys (as well as girls) to have HPV vaccines 2. The vigorous use of antibiotics to treat all bacterial pathogens identified in the urogenital tract 3. The use of antiviral medications to control herpes infections 4. Education about safe sexual practices.
背景
本综述的目的是探讨多种病原体在前列腺癌中是否起作用。
方法
我们回顾了病例对照研究，其中将前列腺癌中的感染性病原体与正常和良性前列腺组织进行了比较。我们还回顾了相关已发表文章中的其他证据。
结果
我们证实高危型人乳头瘤病毒是前列腺癌的一个可能病因。我们认为大肠杆菌、痤疮丙酸杆菌、淋病奈瑟菌、单纯疱疹病毒、爱泼斯坦-巴尔病毒和支原体在慢性前列腺炎和前列腺癌中各自可能有作用，但尚未得到证实。我们认为巨细胞病毒、沙眼衣原体、阴道毛滴虫和多瘤病毒可能有作用，但在前列腺癌中不太可能起作用。
结论与行动
前列腺癌最具影响力的病因似乎是感染引起的慢性炎症。鉴于前列腺癌的高发病率，在不等待更多确凿证据的情况下采取行动很重要。这些行动包括：1. 鼓励所有男孩（以及女孩）接种人乳头瘤病毒疫苗；2. 大力使用抗生素治疗泌尿生殖道中鉴定出的所有细菌病原体；3. 使用抗病毒药物控制疱疹感染；4. 进行安全性行为教育。
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